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        Early signs of tinnitus in a simulation of the mammalian primary auditory cortex

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        907287.pdf (PDF, 140Kb)
        Author
        Metzner, C.
        Menzinger, Melea
        Schweikard, Achim
        Zurowski, Bartosz
        Attention
        2299/16749
        Abstract
        [Poster presentation] The majority of tinnitus cases are related to cochlear dysfunction, leading to altered peripheral input to the central auditory system. These alterations are believed to increase the basic level of neural activity during off-conditions of sound and to diminish the increase in neural activity when sound is presented. As a compensatory means the affected region of primary auditory cortex tries to maximize the difference between basic level activity and sound-induced activity by adapting inhibitory and excitatory influences towards less GABAergic inhibition. This adaptation in turn triggers unmasking of dormant synapses and creation of new connections through axonal sprouting and finally results in a reorganization of tonotopic receptive fields and the manifestation of tinnitus
        Publication date
        2011
        Published in
        BMC Neuroscience
        Published version
        https://doi.org/10.1186/1471-2202-12-S1-P383
        Other links
        http://hdl.handle.net/2299/16749
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