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dc.contributor.authorBaydoun, A. R.
dc.contributor.authorMann, G.E.
dc.date.accessioned2008-02-28T10:04:22Z
dc.date.available2008-02-28T10:04:22Z
dc.date.issued1994
dc.identifier.citationBaydoun , A R & Mann , G E 1994 , ' Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages ' , Biochemical and Biophysical Research Communications , vol. 200 , pp. 726-731 . https://doi.org/10.1006/bbrc.1994.1511
dc.identifier.issn0006-291X
dc.identifier.otherPURE: 123070
dc.identifier.otherPURE UUID: d9325faf-b28d-4105-bd84-5b7cb0de1765
dc.identifier.otherdspace: 2299/1703
dc.identifier.otherScopus: 0028350082
dc.identifier.urihttp://hdl.handle.net/2299/1703
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/0006291X Copyright Elsevier Inc. DOI : 10.1006/bbrc.1994.1511
dc.description.abstractAmino acid transport systems mediating uptake of nitric oxide (NO) synthase inhibitors were characterized in the murine macrophage cell line J774. Treatment of J774 cells with bacterial endotoxin (LPS, 1 μg ml-1, 24 h) selectively increased the transport capacity for NG-monomethyl-L-[14C]arginine (L-NMMA), whereas transport of NG-nitro-L-[3H]arginine (LNNA) was unaffected. Inhibition studies established that the cationic transport system y+ mediates uptake of L-arginine, L-NMMA and NG-iminoethyl-L-ornithine (L-NIO). A neutral transporter, with low substrate specificity and insensitive to LPS, mediates uptake of L-citrulline, L-NNA and its methyl ester L-NAME. We conclude that enhanced expression of the y+ transporter in LPS-stimulated macrophages (1) may facilitate the targeting of selective inhibitors of inducible NO synthase to activated cells generating NO in endotoxin shock.en
dc.language.isoeng
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.rightsOpen
dc.titleSelective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophagesen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
dcterms.dateAccepted1994
rioxxterms.versionofrecordhttps://doi.org/10.1006/bbrc.1994.1511
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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