dc.contributor.author | Baydoun, A. R. | |
dc.contributor.author | Mann, G.E. | |
dc.date.accessioned | 2008-02-28T10:04:22Z | |
dc.date.available | 2008-02-28T10:04:22Z | |
dc.date.issued | 1994 | |
dc.identifier.citation | Baydoun , A R & Mann , G E 1994 , ' Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages ' , Biochemical and Biophysical Research Communications , vol. 200 , pp. 726-731 . https://doi.org/10.1006/bbrc.1994.1511 | |
dc.identifier.issn | 0006-291X | |
dc.identifier.other | PURE: 123070 | |
dc.identifier.other | PURE UUID: d9325faf-b28d-4105-bd84-5b7cb0de1765 | |
dc.identifier.other | dspace: 2299/1703 | |
dc.identifier.other | Scopus: 0028350082 | |
dc.identifier.uri | http://hdl.handle.net/2299/1703 | |
dc.description | Original article can be found at: http://www.sciencedirect.com/science/journal/0006291X Copyright Elsevier Inc. DOI : 10.1006/bbrc.1994.1511 | |
dc.description.abstract | Amino acid transport systems mediating uptake of nitric oxide (NO) synthase inhibitors were characterized in the murine macrophage cell line J774. Treatment of J774 cells with bacterial endotoxin (LPS, 1 μg ml-1, 24 h) selectively increased the transport capacity for NG-monomethyl-L-[14C]arginine (L-NMMA), whereas transport of NG-nitro-L-[3H]arginine (LNNA) was unaffected. Inhibition studies established that the cationic transport system y+ mediates uptake of L-arginine, L-NMMA and NG-iminoethyl-L-ornithine (L-NIO). A neutral transporter, with low substrate specificity and insensitive to LPS, mediates uptake of L-citrulline, L-NNA and its methyl ester L-NAME. We conclude that enhanced expression of the y+ transporter in LPS-stimulated macrophages (1) may facilitate the targeting of selective inhibitors of inducible NO synthase to activated cells generating NO in endotoxin shock. | en |
dc.language.iso | eng | |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | |
dc.title | Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages | en |
dc.contributor.institution | Department of Human and Environmental Sciences | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | https://doi.org/10.1006/bbrc.1994.1511 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |