Show simple item record

dc.contributor.authorBaydoun, A. R.
dc.contributor.authorMann, G.E.
dc.date.accessioned2008-02-28T10:04:22Z
dc.date.available2008-02-28T10:04:22Z
dc.date.issued1994
dc.identifier.citationBaydoun , A R & Mann , G E 1994 , ' Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages ' Biochemical and Biophysical Research Communications , vol. 200 , pp. 726-731 . https://doi.org/10.1006/bbrc.1994.1511
dc.identifier.issn0006-291X
dc.identifier.otherPURE: 123070
dc.identifier.otherPURE UUID: d9325faf-b28d-4105-bd84-5b7cb0de1765
dc.identifier.otherdspace: 2299/1703
dc.identifier.otherScopus: 0028350082
dc.identifier.urihttp://hdl.handle.net/2299/1703
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/0006291X Copyright Elsevier Inc. DOI : 10.1006/bbrc.1994.1511
dc.description.abstractAmino acid transport systems mediating uptake of nitric oxide (NO) synthase inhibitors were characterized in the murine macrophage cell line J774. Treatment of J774 cells with bacterial endotoxin (LPS, 1 μg ml-1, 24 h) selectively increased the transport capacity for NG-monomethyl-L-[14C]arginine (L-NMMA), whereas transport of NG-nitro-L-[3H]arginine (LNNA) was unaffected. Inhibition studies established that the cationic transport system y+ mediates uptake of L-arginine, L-NMMA and NG-iminoethyl-L-ornithine (L-NIO). A neutral transporter, with low substrate specificity and insensitive to LPS, mediates uptake of L-citrulline, L-NNA and its methyl ester L-NAME. We conclude that enhanced expression of the y+ transporter in LPS-stimulated macrophages (1) may facilitate the targeting of selective inhibitors of inducible NO synthase to activated cells generating NO in endotoxin shock.en
dc.language.isoeng
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.titleSelective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophagesen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1006/bbrc.1994.1511
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record