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dc.contributor.authorMarsaux, Cyril F.M.
dc.contributor.authorCelis-Morales, Carlos
dc.contributor.authorLivingstone, Katherine M.
dc.contributor.authorFallaize, Rosalind
dc.contributor.authorKolossa, Silvia
dc.contributor.authorHallmann, Jacqueline
dc.contributor.authorSan-Cristobal, Rodrigo
dc.contributor.authorNavas-Carretero, Santiago
dc.contributor.authorO'Donovan, Clare B.
dc.contributor.authorWoolhead, Clara
dc.contributor.authorForster, Hannah
dc.contributor.authorMoschonis, George
dc.contributor.authorLambrinou, Christina-Paulina
dc.contributor.authorSurwillo, Agnieszka
dc.contributor.authorGodlewska, Magdalena
dc.contributor.authorHoonhout, Jettie
dc.contributor.authorGoris, Annelies
dc.contributor.authorMacready, Anna L.
dc.contributor.authorWalsh, Marianne C.
dc.contributor.authorGibney, Eileen R.
dc.contributor.authorBrennan, Lorraine
dc.contributor.authorManios, Yannis
dc.contributor.authorTraczyk, Iwona
dc.contributor.authorDrevon, Christian A.
dc.contributor.authorLovegrove, Julie A.
dc.contributor.authorMartinez, J. Alfredo
dc.contributor.authorDaniel, Hannelore
dc.contributor.authorGibney, Michael J.
dc.contributor.authorMathers, John C.
dc.contributor.authorSaris, Wim HM
dc.date.accessioned2016-04-27T16:07:38Z
dc.date.available2016-04-27T16:07:38Z
dc.date.issued2016-02-05
dc.identifier.citationMarsaux , C F M , Celis-Morales , C , Livingstone , K M , Fallaize , R , Kolossa , S , Hallmann , J , San-Cristobal , R , Navas-Carretero , S , O'Donovan , C B , Woolhead , C , Forster , H , Moschonis , G , Lambrinou , C-P , Surwillo , A , Godlewska , M , Hoonhout , J , Goris , A , Macready , A L , Walsh , M C , Gibney , E R , Brennan , L , Manios , Y , Traczyk , I , Drevon , C A , Lovegrove , J A , Martinez , J A , Daniel , H , Gibney , M J , Mathers , J C & Saris , W HM 2016 , ' Changes in Physical Activity Following a Genetic-Based Internet-Delivered Personalized Intervention : Randomized Controlled Trial (Food4Me) ' , Journal of Medical Internet Research , vol. 18 , no. 2 , e30 . https://doi.org/10.2196/jmir.5198
dc.identifier.issn1439-4456
dc.identifier.otherPURE: 9848865
dc.identifier.otherPURE UUID: a0d9973e-aeb4-4584-a20c-e23750a0dab6
dc.identifier.otherPubMed: 26851191
dc.identifier.otherScopus: 84962118533
dc.identifier.urihttp://hdl.handle.net/2299/17150
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included
dc.description.abstractBACKGROUND: There is evidence that physical activity (PA) can attenuate the influence of the fat mass- and obesity-associated (FTO) genotype on the risk to develop obesity. However, whether providing personalized information on FTO genotype leads to changes in PA is unknown.OBJECTIVE: The purpose of this study was to determine if disclosing FTO risk had an impact on change in PA following a 6-month intervention.METHODS: The single nucleotide polymorphism (SNP) rs9939609 in the FTO gene was genotyped in 1279 participants of the Food4Me study, a four-arm, Web-based randomized controlled trial (RCT) in 7 European countries on the effects of personalized advice on nutrition and PA. PA was measured objectively using a TracmorD accelerometer and was self-reported using the Baecke questionnaire at baseline and 6 months. Differences in baseline PA variables between risk (AA and AT genotypes) and nonrisk (TT genotype) carriers were tested using multiple linear regression. Impact of FTO risk disclosure on PA change at 6 months was assessed among participants with inadequate PA, by including an interaction term in the model: disclosure (yes/no) × FTO risk (yes/no).RESULTS: At baseline, data on PA were available for 874 and 405 participants with the risk and nonrisk FTO genotypes, respectively. There were no significant differences in objectively measured or self-reported baseline PA between risk and nonrisk carriers. A total of 807 (72.05%) of the participants out of 1120 in the personalized groups were encouraged to increase PA at baseline. Knowledge of FTO risk had no impact on PA in either risk or nonrisk carriers after the 6-month intervention. Attrition was higher in nonrisk participants for whom genotype was disclosed (P=.01) compared with their at-risk counterparts.CONCLUSIONS: No association between baseline PA and FTO risk genotype was observed. There was no added benefit of disclosing FTO risk on changes in PA in this personalized intervention. Further RCT studies are warranted to confirm whether disclosure of nonrisk genetic test results has adverse effects on engagement in behavior change.TRIAL REGISTRATION: ClinicalTrials.gov NCT01530139; http://clinicaltrials.gov/show/NCT01530139 (Archived by WebCite at: http://www.webcitation.org/6XII1QwHz).en
dc.language.isoeng
dc.relation.ispartofJournal of Medical Internet Research
dc.subjectphysical activity
dc.subjectpersonalized intervention
dc.subjectrandomized controlled trial
dc.subjectgenetic testing
dc.subjectdisclosure
dc.subjectbehaviour change
dc.subjectWeb based
dc.titleChanges in Physical Activity Following a Genetic-Based Internet-Delivered Personalized Intervention : Randomized Controlled Trial (Food4Me)en
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionWeight and Obesity Research Group
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionFood Policy, Nutrition and Diet
dc.description.statusPeer reviewed
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.2196/jmir.5198
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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