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dc.contributor.authorOwen, Jade D.
dc.contributor.authorKirton, Stewart B.
dc.contributor.authorEvans, Sara J.
dc.contributor.authorStair, Jacqueline L.
dc.date.accessioned2016-08-01T17:04:24Z
dc.date.available2016-08-01T17:04:24Z
dc.date.issued2016-06-05
dc.identifier.citationOwen , J D , Kirton , S B , Evans , S J & Stair , J L 2016 , ' Elemental fingerprinting of Hypericum perforatum (St John's Wort) herb and preparations using ICP-OES and chemometrics ' Journal of Pharmaceutical and Biomedical Analysis , vol 125 , pp. 15-21 . DOI: 10.1016/j.jpba.2016.02.054en
dc.identifier.issn0731-7085
dc.identifier.otherPURE: 10026412
dc.identifier.otherPURE UUID: 6c232b15-a28a-4446-a51a-9fe677c70d91
dc.identifier.otherScopus: 84960912854
dc.identifier.urihttp://hdl.handle.net/2299/17231
dc.description.abstract© 2016 Elsevier B.V. St. John's wort (SJW) (Hypericum perforatum) is a herbal remedy commonly used to treat mild depression. The elemental profiles of 54 samples (i.e., dry herbs, tablets and capsules) were evaluated by monitoring 25 elements using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The major elemental constituents in the SJW samples were Ca (300-199,000 μg/g), Mg (410-3,530 μg/g), Al (4.4-900 μg/g), Fe (1.154-760 μg/g), Mn (2.4-261 μg/g), Sr (0.88-83.6 μg/g), and Zn (7-64 μg/g). For the sixteen elements that could be reliably quantified, principal component analysis (PCA) was used to investigate underlying patterns in the data. PCA models identified 7 key elements (i.e., Ba, Ca, Cd, Mg, Mo, Ni and Y), which described 85% of the variance in the dataset in the first three principal components. The PCA approach resulted in a general delineation between the three different formulations and provides a basis for monitoring product quality in this manner.en
dc.format.extent7en
dc.language.isoeng
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysisen
dc.rightsen
dc.rights/dk/atira/pure/core/openaccesspermission/embargoed
dc.subjectHypericum perforatumen
dc.subjectICP-OESen
dc.subjectMetal contenten
dc.subjectPrincipal component analysisen
dc.subjectSt. John's worten
dc.titleElemental fingerprinting of Hypericum perforatum (St John's Wort) herb and preparations using ICP-OES and chemometricsen
dc.typeArticleen
dc.contributor.institutionSchool of Life and Medical Sciencesen
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicineen
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicologyen
dc.contributor.institutionNatural Product Chemistry and Drug Designen
dc.contributor.institutionPharmaceutical Chemistryen
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Researchen
dc.contributor.institutionCentre for Hazard Detection and Protection Researchen
dc.contributor.institutionPrescription and Illicit Drug Misuseen
dc.contributor.institutionNanopharmaceuticsen
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substancesen
dc.contributor.institutionHealth Services and Clinical Research Centreen
dc.identifier.doihttp://dx.doi.org/10.1016/j.jpba.2016.02.054
dc.description.statusPeer revieweden
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2016-02-28
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2017-03-04Z
herts.preservation.rarelyaccessedtrue
herts.date.embargo2017-03-04Z


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