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dc.contributor.authorTurner, Rob
dc.contributor.authorWeaver, Sean
dc.contributor.authorCaserta, Francesco
dc.contributor.authorBrown, Marc B
dc.date.accessioned2017-01-23T18:38:25Z
dc.date.available2017-01-23T18:38:25Z
dc.date.issued2016-04-30
dc.identifier.citationTurner , R , Weaver , S , Caserta , F & Brown , M B 2016 , ' A Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onychomycosis ' International Journal of Pharmaceutical Compounding , vol 20 , no. 1 , pp. 71-80 .
dc.identifier.issn1092-4221
dc.identifier.otherPURE: 10268485
dc.identifier.otherPURE UUID: fb360679-1399-4c3c-a9a4-8f92be6037f9
dc.identifier.otherPubMed: 27125057
dc.identifier.otherScopus: 84973410235
dc.identifier.urihttp://hdl.handle.net/2299/17542
dc.descriptionTurner, R., Weaver, S., Caserta, F., Brown, M B., 'A Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onyhomycosis', International Journal of Pharmaceutical Compounding, Vol 20(1): 71-80, Jan/Fab 2016. The version of record is available online at: https://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4103
dc.description.abstractThe aim of this study was to use in vitro nail models to investigate the potential of a novel base formulation (Recura) containing either fluconazole or miconazole for the treatment of onychomycosis in comparison to two commercial comparators (Jublia and a Penlac generic). Initially, a modified Franz cell was used, where sections of human nail served as the barrier through which drug penetrated into an agar-filled chamber infected with dermatophytes. A second study was performed using a novel infected nail model where dermatophytes grew into human nail and adenosine triphosphate levels were used as biological marker for antimicrobial activity. The novel enhancing system Recura increased the permeation of both existing drugs through human nail sections mounted in a modified Franz cell. Furthermore, the infected nail model also confirmed that the system also enhanced the permeation through infected nail resulting in a decrease in adenosine triphosphate levels superior (P ≤ 0.05) to Penlac generic and equivalent (P > 0.05) to the commercial comparator Jublia. This study demonstrated that with the use of a novel permeation-enhancing formulation base, Recura enhances delivery of miconazole and fluconazole when applied ungually such that the efficacy was equivalent or superior to commercial comparators. Such a topically applied system has the possibility of overcoming the systemic side effects of antifungals when taken orally.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutical Compounding
dc.subjectAdenosine Triphosphate
dc.subjectAdministration, Topical
dc.subjectAntifungal Agents
dc.subjectArthrodermataceae
dc.subjectChemistry, Pharmaceutical
dc.subjectDrug Delivery Systems
dc.subjectFluconazole
dc.subjectHumans
dc.subjectMiconazole
dc.subjectNails
dc.subjectOnychomycosis
dc.subjectPermeability
dc.subjectPyridones
dc.subjectTriazoles
dc.titleA Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onychomycosisen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionSkin and Nail Group
dc.contributor.institutionAirway Group
dc.contributor.institutionBioadhesive Drug Delivery Group
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionToxicology
dc.description.statusPeer reviewed
dc.identifier.urlhttps://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4103
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeclosedAccess


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