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dc.contributor.authorMartinotti, Giovanni
dc.contributor.authorSantacroce, Rita
dc.contributor.authorPapanti, Duccio
dc.contributor.authorElgharably, Yasmine
dc.contributor.authorPrilutskaya, Mariya
dc.contributor.authorCorazza, Ornella
dc.date.accessioned2018-01-30T22:21:43Z
dc.date.available2018-01-30T22:21:43Z
dc.date.issued2017-04-13
dc.identifier.citationMartinotti , G , Santacroce , R , Papanti , D , Elgharably , Y , Prilutskaya , M & Corazza , O 2017 , ' Synthetic Cannabinoids : psychopharmacology, clinical aspects, and psy-chotic onset ' , CNS & Neurological Disorders - Drug Targets , vol. 16 , no. 5 , pp. 567-575 . https://doi.org/10.2174/1871527316666170413101839
dc.identifier.issn1871-5273
dc.identifier.otherPURE: 11446614
dc.identifier.otherPURE UUID: ffd5c365-cc8f-43de-86ec-d724523ffc7e
dc.identifier.otherPubMed: 28412921
dc.identifier.otherScopus: 85028977575
dc.identifier.urihttp://hdl.handle.net/2299/19651
dc.descriptionThis document is the Accepted Manuscript version of the following article: Giovanni Martinotti, Rita Santacroce, Duccio Papanti, Yasmine Elgharably, Mariya Prilutskaya, Ornella Corazza, ‘Synthetic Cannabinoids: Psychopharmacology, Clinical Aspects, and Psychotic Onset’, CNS & Neurological Disorders – Drug Targets, Vol. 16, 2017. Under embargo. Embargo end date: 13 April 2018. The published manuscript is available at EurekaSelect via: https://doi.org/10.2174/1871527316666170413101839. Published by Bentham Science.
dc.description.abstractSynthetic Cannabinoids (SC) are the widest and most diffused class of Novel Psychoactive Substances. SC are chemically heterogeneous and structurally dissimilar from delta-9-tetrahydrocannabinol, being full agonists of the endocannabinoid system receptors CB1 and CB2. Desired effects include euphoria, talkativeness, feelings of joy and laughter, relaxation. With respect to cannabis, SC intake may also be associated with quicker arise of the effects, shorter duration of action, and larger levels of hangover. SC are more psychoactive than cannabis: symptoms may include a wide range of clinically relevant posi-tive, negative and cognitive psychopathological symptoms that mimic symptoms of schizophrenia. The risk of two widespread symptoms of SC intoxication, namely agitation and cardiotoxicity, exceeds this of traditional cannabis of 3.8 and 9.2 times respectively. A number of deaths have been related to SC ingestion, either on their own or in combination with other recreational drugs. Prompt and reliable in-formation available for health professionals, more specific analytic techniques, and designed preventive strategies are all required to face this unprecedented challenge.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofCNS & Neurological Disorders - Drug Targets
dc.rightsEmbargoed
dc.subjectNovel Psychoactive Substances
dc.subjectsynthetic cannabinoids
dc.subjectcannabis
dc.subjectintoxication
dc.titleSynthetic Cannabinoids : psychopharmacology, clinical aspects, and psy-chotic onseten
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Clinical Practice, Safe Medicines and Drug Misuse Research
dc.contributor.institutionDepartment of Pharmacy, Pharmacology and Postgraduate Medicine
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.description.statusPeer reviewed
dc.date.embargoedUntil2018-04-13
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Accepted Version
dcterms.dateAccepted2017-04-13
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.2174/1871527316666170413101839
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2018-04-13
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.date.embargo2018-04-13
herts.rights.accesstypeEmbargoed


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