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dc.contributor.authorCheong, Yuen Ki
dc.contributor.authorHuang, Mei
dc.contributor.authorDetsch, Rainer
dc.contributor.authorBoccaccini, Aldo R.
dc.contributor.authorRen, Guogang
dc.date.accessioned2018-09-25T09:11:45Z
dc.date.available2018-09-25T09:11:45Z
dc.date.issued2017-12-08
dc.identifier.citationCheong , Y K , Huang , M , Detsch , R , Boccaccini , A R & Ren , G 2017 , ' Biological evaluations of novel 2,3,3-Trisphosphonate in osteoclastic and osteoblastic activities ' General Medicine Open , vol 2 , no. 1 , pp. 1-10 . DOI: 10.15761/GMO.1000121
dc.identifier.issn2515-4737
dc.identifier.otherPURE: 12889221
dc.identifier.otherPURE UUID: a2f45c0c-393a-4d42-be16-332899a3a733
dc.identifier.urihttp://hdl.handle.net/2299/20639
dc.description.abstractBisphosphonates (BPs) are the first line treatment for many bone diseases including hypercalcimia associated with bone malignancies. In this paper, we introduce a new analogue of bisphosphonate called the 2,3,3-Trisphosphonate (2,3,3-TriPP) that was synthesised in a two steps reaction. In vitro investigations using a medically known bisphosphonate (Etidronate) and the 2,3,3-TrisPP were performed with an aim to evaluate biological effect of this novel compound in major bone cells. 2,3,3-TrisPP showed to have potential to supress the bone resorption process, as our data found that this novel compound exhibited cytotoxic effect in osteoclastic cells at a low concentration of 0.172 mg/mL (LC50). A molecular docking computational simulation calculated a high level of binding affinity between the human farnesyl pyrophosphate synthase (hFPPS) and 2,3,3-TrisPP. This calculation suggested 2,3,3TrisPP may have undergone the mevalonate pathway to prevent the prenylation step during biosynthesis and subsequently resulted in the deactivation of osteoclastic cells. Finally, high levels of osteoblast mineralisation potentials were recorded upon treatments with 2,3,3-TrisPP (0.01-0.1 mg/ml), which implied 2,3,3-TrsiPP may also facilitate bone regeneration.en
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofGeneral Medicine Open
dc.rights/dk/atira/pure/core/openaccesspermission/open
dc.titleBiological evaluations of novel 2,3,3-Trisphosphonate in osteoclastic and osteoblastic activitiesen
dc.contributor.institutionSchool of Engineering and Technology
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Engineering and Technology
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2017-12-04
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.15761/GMO.1000121
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.rights.accesstypeopenAccess


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