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dc.contributor.authorSrivastava, Arohi
dc.contributor.authorMohan, Sharad
dc.contributor.authorMauchline, Tim H.
dc.contributor.authorDavies, Keith
dc.date.accessioned2018-11-17T02:13:33Z
dc.date.available2018-11-17T02:13:33Z
dc.date.issued2019-01-01
dc.identifier.citationSrivastava , A , Mohan , S , Mauchline , T H & Davies , K 2019 , ' Evidence for diversifying selection of genetic regions of encoding putative collagen-like host-adhesive fibers in Pasteuria penetrans ' , FEMS Microbiology Ecology , vol. 95 , no. 1 , fiy217 . https://doi.org/10.1093/femsec/fiy217
dc.identifier.issn0168-6496
dc.identifier.otherORCID: /0000-0001-6060-2394/work/62750585
dc.identifier.urihttp://hdl.handle.net/2299/20797
dc.description© FEMS 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.description.abstractPasteuria spp. belong to a group of genetically diverse endospore-forming bacteria (phylum: Firmicutes) that are known to parasitize plant-parasitic nematodes and water fleas (Daphnia spp.). Collagen-like fibres form the nap on the surface of endospores and the genes encoding these sequences have been hypothesised to be involved in the adhesion of the endospores of Pasteuria spp. to their hosts. We report a group of 17 unique collagen-like genes putatively encoded by Pasteuria penetrans (strain: Res148) that formed five different phylogenetic clusters and suggest that collagen-like proteins are an important source of genetic diversity in animal pathogenic Firmicutes including Pasteuria. Additionally, and unexpectedly, we identified a putative collagen-like sequence which had a very different sequence structure to the other collagen-like proteins but was similar to the protein sequences in Megaviruses that are involved in host-parasite interactions. We, therefore, suggest that these diverse endospore surface proteins in Pasteuria are involved in biological functions, such as cellular adhesion; however, they are not of monophyletic origin and were possibly obtained de novo by mutation or possibly through selection acting upon several historic horizontal gene transfer events.en
dc.format.extent8
dc.format.extent1020924
dc.language.isoeng
dc.relation.ispartofFEMS Microbiology Ecology
dc.subjectAdhesion
dc.subjectBacterial collagens
dc.subjectBclA
dc.subjectEndospore
dc.subjecthair-like nap
dc.subjectPathogenicity
dc.subjectMicrobiology
dc.subjectEcology
dc.subjectApplied Microbiology and Biotechnology
dc.titleEvidence for diversifying selection of genetic regions of encoding putative collagen-like host-adhesive fibers in Pasteuria penetransen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.contributor.institutionGeography, Environment and Agriculture
dc.contributor.institutionCrop Protection and Climate Change
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85056583188&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1093/femsec/fiy217
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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