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dc.contributor.authorKosgodage, Uchini S
dc.contributor.authorUysal-Onganer, Pinar
dc.contributor.authorMacLatchy, Amy
dc.contributor.authorMould, Rhys
dc.contributor.authorNunn, Alistair
dc.contributor.authorGuy, Geoffrey
dc.contributor.authorKraev, Igor
dc.contributor.authorChatterton, Nicholas
dc.contributor.authorInal, Jameel
dc.contributor.authorThomas, E. Louise
dc.contributor.authorBell, Jimmy
dc.contributor.authorLange, Sigrun
dc.date.accessioned2019-01-08T16:15:02Z
dc.date.available2019-01-08T16:15:02Z
dc.date.issued2019-03-01
dc.identifier.citationKosgodage , U S , Uysal-Onganer , P , MacLatchy , A , Mould , R , Nunn , A , Guy , G , Kraev , I , Chatterton , N , Inal , J , Thomas , E L , Bell , J & Lange , S 2019 , ' Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells ' , Translational Oncology , vol. 12 , no. 3 , pp. 513-522 . https://doi.org/10.1016/j.tranon.2018.12.004
dc.identifier.issn1944-7124
dc.identifier.urihttp://hdl.handle.net/2299/20929
dc.descriptionCopyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
dc.description.abstractGlioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key-mediators for cellular communication through transfer of proteins and genetic material. Cancers, such as GBM, use EV release for drug-efflux, pro-oncogenic signaling, invasion and immunosuppression; thus the modulation of EV release and cargo is of considerable clinical relevance. As EV-inhibitors have been shown to increase sensitivity of cancer cells to chemotherapy, and we recently showed that cannabidiol (CBD) is such an EV-modulator, we investigated whether CBD affects EV profile in GBM cells in the presence and absence of temozolomide (TMZ). Compared to controls, CBD-treated cells released EVs containing lower levels of pro-oncogenic miR21 and increased levels of anti-oncogenic miR126; these effects were greater than with TMZ alone. In addition, prohibitin (PHB), a multifunctional protein with mitochondrial protective properties and chemoresistant functions, was reduced in GBM cells following 1 h CBD treatment. This data suggests that CBD may, via modulation of EVs and PHB, act as an adjunct to enhance treatment efficacy in GBM, supporting evidence for efficacy of cannabinoids in GBM.en
dc.format.extent10
dc.format.extent1498749
dc.language.isoeng
dc.relation.ispartofTranslational Oncology
dc.subjectOncology
dc.subjectCancer Research
dc.titleCannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cellsen
dc.contributor.institutionDepartment of Biological and Environmental Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionBiosciences Research Group
dc.contributor.institutionExtracellular Vesicle Research Unit
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85059111569&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1016/j.tranon.2018.12.004
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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