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dc.contributor.authorCarta, Mauro Giovanni
dc.contributor.authorFineberg, Naomi
dc.contributor.authorMoro, Maria Francesca
dc.contributor.authorPreti, Antonio
dc.contributor.authorRomano, Ferdinando
dc.contributor.authorBalestrieri, Matteo
dc.contributor.authorCaraci, Filippo
dc.contributor.authorDell'Osso, Liliana
dc.contributor.authorDisciascio, Guido
dc.contributor.authorDrago, Filippo
dc.contributor.authorHardoy, Maria Carolina
dc.contributor.authorRoncone, Rita
dc.contributor.authorMinerba, Luigi
dc.contributor.authorFaravelli, Carlo
dc.contributor.authorAngst, Jules
dc.date.accessioned2020-05-04T15:00:29Z
dc.date.available2020-05-04T15:00:29Z
dc.date.issued2020-03-31
dc.identifier.citationCarta , M G , Fineberg , N , Moro , M F , Preti , A , Romano , F , Balestrieri , M , Caraci , F , Dell'Osso , L , Disciascio , G , Drago , F , Hardoy , M C , Roncone , R , Minerba , L , Faravelli , C & Angst , J 2020 , ' The Burden of Comorbidity Between Bipolar Spectrum and Obsessive-Compulsive Disorder in an Italian Community Survey ' , Frontiers in Psychiatry , vol. 11 , 188 . https://doi.org/10.3389/fpsyt.2020.00188
dc.identifier.issn1664-0640
dc.identifier.urihttp://hdl.handle.net/2299/22649
dc.description© 2020 Carta, Fineberg, Moro, Preti, Romano, Balestrieri, Caraci, Dell’Osso, Disciascio, Drago, Hardoy, Roncone, Minerba, Faravelli and Angst. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY: https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.description.abstractBackground: The impact of the comorbidity between Obsessive-Compulsive Disorder (OCD) and Bipolar Disorder Spectrum (BDS) remains to be clarified. The objective of this study was to examine the lifetime prevalence of OCD, the strength of the association of OCD with comorbid BDS and the role of comorbidity of OCD with BDS in the impairment of health-related quality of life (HRQoL) in an Italian community survey. Methods: The study is a community survey. The sample (N = 2,267; women: 55.3%) was randomly selected after stratification by sex and four age groups from the municipal records of the adult population of one urban, one suburban, and at least one rural area in six Italian regions. Physicians using a semi-structured interview (Advanced Tools and Neuropsychiatric Assessment Schedule, ANTAS-SCID) made Diagnostic and Statistical Manual of Mental Disorders – 4th revision (DSM-IV) diagnoses of OCD, Major Depressive Disorder (MDD) and Bipolar Disorder (BD). HR-QoL was measured by the Health Survey Short Form (SF-12). Lifetime Hypomania and subthreshold hypomania were screened by the Mood Disorder Questionnaire (MDQ). BDS was defined as the sum of people shown to be positive for hypomania by the MDQ—with or without a mood disorder diagnosis—plus people with a BD-DSMIV diagnosis even if negative for hypomania at the MDQ. Results: Overall, 44 subjects were diagnosed with OCD, 6 with MDD and 1 with BD. The lifetime prevalence of OCD was 1.8% in men (n = 18) and 2.0% in women (n = 26). MDD with lifetime subthreshold hypomania (i.e., people screened positive at the MDQ, even without diagnosed mania or hypomania at the interview) was associated with OCD (OR = 18.15, CI 95% 2.45–103.67); MDD without subthreshold hypomania (and screened negative at the MDQ) was not (OR = 2.33, CI 95% 0.69–7.01). People with BDS were strongly associated with OCD (OR = 10.5, CI 95% 4.90–12.16,). People with OCD and BDS showed significantly poorer HR-QoL than people with OCD without BDS (F = 9.492; P < 0.003). Discussion: The study found a strong association between BDS and OCD. BDS comorbid with OCD was associated with more severe impairment of HR-QoL than OCD without comorbid BDS. Identification of symptoms of hypomania, including subthreshold symptoms, may therefore be important in people with OCD as they might predict a course with poorer HR-QoL.en
dc.format.extent7
dc.format.extent354474
dc.language.isoeng
dc.relation.ispartofFrontiers in Psychiatry
dc.subjectbipolar disorder
dc.subjectbipolar spectrum
dc.subjectcommunity survey
dc.subjectepidemiology
dc.subjectobsessive compulsive disorders
dc.subjectquality of life
dc.subjectPsychiatry and Mental health
dc.titleThe Burden of Comorbidity Between Bipolar Spectrum and Obsessive-Compulsive Disorder in an Italian Community Surveyen
dc.contributor.institutionCognitive Neuropsychology
dc.contributor.institutionDepartment of Clinical and Pharmaceutical Sciences
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85083291302&partnerID=8YFLogxK
rioxxterms.versionofrecord10.3389/fpsyt.2020.00188
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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