StopCOVID cohort : An observational study of 3,480 patients admitted to the Sechenov University hospital network in Moscow city for suspected COVID-19 infection
dc.contributor.author | Munblit, Daniel | |
dc.contributor.author | Nekliudov, Nikita A | |
dc.contributor.author | Bugaeva, Polina | |
dc.contributor.author | Blyuss, Oleg | |
dc.contributor.author | Kislova, Maria | |
dc.contributor.author | Listovskaya, Ekaterina | |
dc.contributor.author | Gamirova, Aysylu | |
dc.contributor.author | Shikhaleva, Anastasia | |
dc.contributor.author | Belyaev, Vladimir | |
dc.contributor.author | Timashev, Petr | |
dc.contributor.author | Warner, John O | |
dc.contributor.author | Comberiati, Pasquale | |
dc.contributor.author | Apfelbacher, Christian | |
dc.contributor.author | Bezrukov, Evgenii | |
dc.contributor.author | Politov, Mikhail E | |
dc.contributor.author | Yavorovskiy, Andrey | |
dc.contributor.author | Bulanova, Ekaterina | |
dc.contributor.author | Tsareva, Natalya | |
dc.contributor.author | Avdeev, Sergey | |
dc.contributor.author | Kapustina, Valentina A | |
dc.contributor.author | Pigolkin, Yuri I | |
dc.contributor.author | Dankwa, Emmanuelle A | |
dc.contributor.author | Kartsonaki, Christiana | |
dc.contributor.author | Pritchard, Mark G | |
dc.contributor.author | Victor, Fomin | |
dc.contributor.author | Svistunov, Andrey A | |
dc.contributor.author | Butnaru, Denis | |
dc.contributor.author | Glybochko, Petr | |
dc.date.accessioned | 2020-10-23T12:00:02Z | |
dc.date.available | 2020-10-23T12:00:02Z | |
dc.date.issued | 2020-10-09 | |
dc.identifier.citation | Munblit , D , Nekliudov , N A , Bugaeva , P , Blyuss , O , Kislova , M , Listovskaya , E , Gamirova , A , Shikhaleva , A , Belyaev , V , Timashev , P , Warner , J O , Comberiati , P , Apfelbacher , C , Bezrukov , E , Politov , M E , Yavorovskiy , A , Bulanova , E , Tsareva , N , Avdeev , S , Kapustina , V A , Pigolkin , Y I , Dankwa , E A , Kartsonaki , C , Pritchard , M G , Victor , F , Svistunov , A A , Butnaru , D & Glybochko , P 2020 , ' StopCOVID cohort : An observational study of 3,480 patients admitted to the Sechenov University hospital network in Moscow city for suspected COVID-19 infection ' , Clinical infectious diseases . https://doi.org/10.1093/cid/ciaa1535 | |
dc.identifier.issn | 1058-4838 | |
dc.identifier.other | ORCID: /0000-0002-0194-6389/work/82756024 | |
dc.identifier.uri | http://hdl.handle.net/2299/23315 | |
dc.description | © 2020 Oxford University Press. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The version of record is available online at: https://doi.org/10.1093/cid/ciaa1535. | |
dc.description.abstract | BACKGROUND: The epidemiology, clinical course, and outcomes of COVID-19 patients in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically-diagnosed COVID-19 in real-life settings is lacking. METHODS: We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow, between April 8 and May 28, 2020. RESULTS: Of the 4261 patients hospitalised for suspected COVID-19, outcomes were available for 3480 patients (median age 56 years (interquartile range 45-66). The commonest comorbidities were hypertension, obesity, chronic cardiac disease and diabetes. Half of the patients (n=1728) had a positive RT-PCR while 1748 were negative on RT-PCR but had clinical symptoms and characteristic CT signs suggestive of COVID-19 infection.No significant differences in frequency of symptoms, laboratory test results and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive SARS-CoV-2 RT-PCR.In a multivariable logistic regression model the following were associated with in-hospital mortality; older age (per 1 year increase) odds ratio [OR] 1.05 (95% confidence interval (CI) 1.03 - 1.06); male sex (OR 1.71, 1.24 - 2.37); chronic kidney disease (OR 2.99, 1.89 - 4.64); diabetes (OR 2.1, 1.46 - 2.99); chronic cardiac disease (OR 1.78, 1.24 - 2.57) and dementia (OR 2.73, 1.34 - 5.47). CONCLUSIONS: Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features were sufficient to diagnoseCOVID-19 infection indicating that laboratory testing is not critical in real-life clinical practice. | en |
dc.format.extent | 1276780 | |
dc.language.iso | eng | |
dc.relation.ispartof | Clinical infectious diseases | |
dc.title | StopCOVID cohort : An observational study of 3,480 patients admitted to the Sechenov University hospital network in Moscow city for suspected COVID-19 infection | en |
dc.contributor.institution | School of Physics, Astronomy and Mathematics | |
dc.contributor.institution | School of Physics, Engineering & Computer Science | |
dc.contributor.institution | Department of Physics, Astronomy and Mathematics | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2021-10-09 | |
rioxxterms.versionofrecord | 10.1093/cid/ciaa1535 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true |