dc.contributor.author | Hendra, Heidy | |
dc.contributor.author | Sridharan, Sivakumar | |
dc.contributor.author | Farrington, Ken | |
dc.contributor.author | Davenport, Andrew | |
dc.date.accessioned | 2022-05-25T11:30:01Z | |
dc.date.available | 2022-05-25T11:30:01Z | |
dc.date.issued | 2022-05-06 | |
dc.identifier.citation | Hendra , H , Sridharan , S , Farrington , K & Davenport , A 2022 , ' Characteristics of Frailty in Haemodialysis Patients ' , Gerontology and Geriatric Medicine (GGM) , vol. 8 . https://doi.org/10.1177/23337214221098889 | |
dc.identifier.issn | 2333-7214 | |
dc.identifier.other | PubMedCentral: PMC9083032 | |
dc.identifier.other | Jisc: 299444 | |
dc.identifier.other | publisher-id: 10.1177_23337214221098889 | |
dc.identifier.uri | http://hdl.handle.net/2299/25527 | |
dc.description | © The Author(s) 2022. This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.description.abstract | Background: Both frailty and cachexia increase mortality in haemodialysis (HD) patients. The clinical frailty score (CFS) is a seven-point scale and less complex than other cachexia and frailty assessments. We wished to determine the characteristics of frail HD patients using the CFS. Methods: Single centre cross-sectional study of HD patients completing physical activity questionnaires with bioimpedance measurements of body composition and hand grip strength (HGS). Results: We studied 172 HD patients. The CFS classified 54 (31.4%) as frail, who were older (70.4±12.2 vs 56.2 ± 16.1 years, p < 0.001), greater modified Charlson co-morbidity (3 (2–3) versus 1.5 (0–3), p < 0.001), and body fat (33 (25.4–40.2) versus 26.2 (15.8–34) %, p < 0.01), but lower total energy expenditure (1720 (1574–1818) versus 1870 (1670–2194) kcal/day, p < 0.01), lean muscle mass index (9.1 (7.7–10.1) versus 9.9 (8.9–10.8) kg/m2), and HGS (15.3 (10.3–21.9) versus 23.6 (16.7–34.4) kg), both p < 0.001. On multivariable logistic analysis, frailty was independently associated with lower active energy expenditure (odds ratio (OR) 0.98, 95% confidence limits (CL) 0.98–0.99, p = 0.001), diabetes (OR 5.09, CL 1.06–16.66) and HGS (OR 0.92, CL 0.86–0.98). Discussion: Frail HD patients reported less active energy expenditure, associated with reduced muscle mass and strength. Frail patients were more likely to have greater co-morbidity, particularly diabetes. Whether physical activity programmes can improve frailty remains to be determined. | en |
dc.format.extent | 9 | |
dc.format.extent | 604397 | |
dc.language.iso | eng | |
dc.relation.ispartof | Gerontology and Geriatric Medicine (GGM) | |
dc.subject | Brief Report | |
dc.subject | diseases | |
dc.subject | nursing | |
dc.subject | frailty | |
dc.subject | diabetes | |
dc.subject | obesity | |
dc.subject | Geriatrics and Gerontology | |
dc.title | Characteristics of Frailty in Haemodialysis Patients | en |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | University of Hertfordshire | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85129860163&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1177/23337214221098889 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |