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        The neuropsychology of the schizo-obsessive subtype of schizophrenia : a new analysis

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        904083.pdf (PDF, 114Kb)
        Author
        Patel, D.D.
        Laws, K.R.
        Padhi, A.
        Farrow, J.
        Mukhopadhaya, K.
        Krishnaiah, R.
        Fineberg, Naomi
        Attention
        2299/5829
        Abstract
        Background : Interest in the neuro-cognitive profile of patients with schizophrenia and co-morbid obsessive compulsive disorder (schizo-OCD) is rising in response to reports of high co-morbidity rates. Whereas schizophrenia has been associated with global impairment in a wide range of neuro-cognitive domains, OCD is associated with specific deficits featuring impaired performance on tasks of motor and cognitive inhibition involving frontostriatal neuro-circuitry. Method : We compared cognitive function using the CANTAB battery in patients with schizo-OCD (n=12) and a schizophrenia group without OCD symptoms (n=16). The groups were matched for IQ, gender, age, medication, and duration of illness. Results : The schizo-OCD patients made significantly more errors on a task of attentional set-shifting (ID-ED set-shift task). By contrast, no significant differences emerged on the Stockings of Cambridge task, the Cambridge Gamble Task or the Affective Go/NoGo tasks. No correlation emerged between ID-ED performance and severity of schizophrenia, OCD or depressive symptoms, consistent with neurocognitive impairment holding trait rather than state-marker status. Schizo-obsessives also exhibited a trend toward more motor tics emphasizing a neurological contribution to the disorder. Conclusion : Our findings reveal a more severe attentional set-shifting deficit and neurological abnormality that may be fundamental to the neuro-cognitive profile of schizo-OCD. The clinical implications of these impairments merit further exploration in larger studies.
        Publication date
        2010
        Published in
        Psychological Medicine
        Published version
        https://doi.org/10.1017/S0033291709991255
        Other links
        http://hdl.handle.net/2299/5829
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