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Browsing University of Hertfordshire by Author "Kukol, A."
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Methyl-group effect on the proton affinity of methylated acetophenons studied by two mass-spectrometric techniques
Kukol, A.; Strehle, F.; Thielking, G.; Grutzmacher, H. F. (1993-10)The proton affinities (PA) of all isomeric dimethylacetophenones were determined using the 'kinetic method' with a tandem mass spectrometer and by measurements of the proton transfer equilibrium in the gas phase by Fourier ... -
Model of a Putative Pore : The Pentameric -Helical Bundle of SARS Coronavirus E Protein in Lipid Bilayers
Torres, J.; Parthasarathy, K.; Lin, X.; Saravanan, R.; Kukol, A.; Liu, D.X. (2006) -
Molecular Modeling of Proteins
Kukol, A.; School of Life and Medical Sciences; Biosciences Research Group; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Centre for Future Societies Research (Springer Nature, 2015-01-01) -
Phospholemman Transmembrane Structure Reveals Potential Interactions with Na+/K+-ATPase
Beevers, A.J.; Kukol, A. (2007) -
Secondary structure, orientation, and oligomerization of phospholemman, a cardiac transmembrane protein
Beevers, A.J.; Kukol, A. (2006) -
Site-specific examination of secondary structure and orientation determination in membrane proteins: The peptidic C-13=O-18 group as a novel infrared probe
Torres, J.; Kukol, A.; Goodman, J. M.; Arkin, I.T. (2001-11)Detailed site-specific information can be exceptionally useful in structural studies of macromolecules in general and proteins in particular. Stich information is usually obtained from spectroscopic studies using a label/probe ... -
Solid-state O-17 NMR of amino acids
Pike, K. J.; Lemaitre, V.; Kukol, A.; Anupold, T.; Samoson, A.; Howes, A. P.; Watts, A.; Smith, M. E.; Dupree, R. (2004-07-01)O-17 solid-state NMR from 14 amino acids is reported here, greatly increasing the number investigated. In most cases well-separated resonances from carbonyl and hydroxyl oxygens with distinct second-order quadrupolar line ... -
Solid-state O-17 NMR spectroscopy of a phospholemman transmembrane domain protein : Implications for the limits of detecting dilute 170 sites in biomaterials
Wong, Alan; Beevers, Andrew J.; Kukol, A.; Dupree, Ray; Smith, Mark E. (2008-05)The O-17-'diluted' glycine-14 sites in a phospholemman (PLM) transmembrane domain protein are characterized by solid-state O-17 NMR spectroscopy. The PLM transmembrane domain is an a-helical tetramer unit of four 28-residue ... -
Structure and dynamics of the kinase IKK-β – A key regulator of the NF-kappa B transcription factor
Kalia, Munishikha; Kukol, A. (2011)The inhibitor κB kinase-β (IKK-β) phosphorylates the NF-κB inhibitor protein IκB leading to the translocation of the transcription factor NF-κB to the nucleus. The transcription factor NF-κB and consequently IKK-β are ... -
A Structure for the Trimeric MHC Class II-associated Invariant Chain Transmembrane Domain
Kukol, A.; Torres, J.; Arkin, I.T. (2002) -
The Structure of Ghrelin
Kukol, A. (2007)The structure of ghrelin, a 28-residue octanoylated peptide hormone, is only known up to the level of primary structure identifying an active core of residues 1-5 or 1-4 including octanoyl-Ser3 as necessary to elicit ... -
The structure of the HIV-1 Vpu ion channel: modelling and simulation studies
Cordes, F. S.; Kukol, A.; Forrest, L. R.; Arkin, I.T.; Sansom, M. S. P.; Fischer, W. B. (2001-06-06)Vpu is an 81 amino acid auxiliary protein in HIV-1 which exhibits channel activity. We used two homo-pentameric bundles with the helical transmembrane segments derived from FTIR spectroscopy in combination with a global ... -
Structure of the Influenza C virus CM2 protein transmembrane domain obtained by site-specific infrared dichroism and global molecular dynamics searching
Kukol, A.; Arkin, I.T. (2000-02-11)The 115-residue protein CM2 from Influenza C virus has been recently characterized as a tetrameric integral membrane glycoprotein. infrared spectroscopy and site-directed infrared dichroism were utilized here to determine ... -
Systematic molecular dynamics searching in a lipid bilayer: Application to the glycophorin A and oncogenic ErbB-2 transmembrane domains
Beevers, A.J.; Kukol, A. (2006) -
Transmembrane protein models based on high-throughput molecular dynamics simulations with experimental constraints
Beevers, A.J.; Kukol, A. (2008) -
Use of a single glycine residue to determine the tilt and orientation of a transmembrane helix : A new structural label for infrared spectroscopy
Torres, J.; Kukol, A.; Arkin, I.T. (2000-12)Site-directed dichroism is an emerging technique for the determination of membrane protein structure. However, due to a number of factors, among which is the high natural abundance of C-13, the use of this technique has ... -
Vpu transmembrane peptide structure obtained by site-specific Fourier transform infrared dichroism and global molecular dynamics searching
Kukol, A.; Arkin, I.T. (1999-09)The recently developed method of site-directed Fourier transform infrared dichroism for obtaining orientational constraints of oriented polymers is applied here to the transmembrane domain of the vpu protein from the human ...