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Browsing University of Hertfordshire by Author "Vafeiadou, Katerina"
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Neuroinflammation and its modulation by flavonoids
Vafeiadou, Katerina; Vauzour, David; Spencer, J. P. E. (2007-09)There is increasing evidence to suggest that neuroinflammatory processes contribute to the cascade of events that lead to the progressive neuronal damage observed in neurodegenerative disorders such as Parkinson's disease ... -
The neuroprotective potential of flavonoids : a multiplicity of effects
Vauzour, David; Vafeiadou, Katerina; Rodriguez-Mateos, Ana; Rendeiro, Catarina; Spencer, Jeremy P. E. (2008-12)Flavonoids exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to ... -
Number of endothelial progenitor cells are associated with body composition, but not fat intake or blood lipids
Altowaijri, Hana; Weech, Michelle; Vafeiadou, Katerina; Hobby, Emma; Wu, Sheila; Madden, Jackie; Jackson, Kim G.; Todd, Sue; Yaqoob, Parveen; Lovegrove, Julie A. (2011) -
Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1 : implications for Parkinson's disease and protection by polyphenols
Vauzour, David; Ravaioli, Giulia; Vafeiadou, Katerina; Rodriguez-Mateos, Ana; Angeloni, Cristina; Spencer, Jeremy P. E. (2008-08-15)Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-c ... -
Polyphenols
Vauzour, David; Vafeiadou, Katerina; Spencer, Jeremy P E (Willey-Blackwell, Oxford, UK, 2012) -
Proteomic biomarkers of peripheral blood mononuclear cells obtained from postmenopausal women undergoing an intervention with soy isoflavones
Fuchs, Dagmar; Vafeiadou, Katerina; Hall, Wendy L.; Daniel, Hannelore; Williams, Christine M; Schroot, Joyce H.; Wenzel, Uwe (2007-11)The incidence of cardiovascular diseases increases after menopause, and soy consumption is suggested to inhibit disease development. -
The reaction of flavonoid metabolites with peroxynitrite
Pollard, Susan E.; Kuhnle, Gunter G. C.; Vauzour, David; Vafeiadou, Katerina; Tzounis, Xenofon; Whiteman, Matthew; Rice-Evans, Catherine; Spencer, Jeremy P. E. (2006-12-01)There is much interest in the bioactivity of in vivo flavonoid metabolites. We report for the first time the hierarchy of reactivity of flavonoid metabolites with peroxynitrite and characterise novel reaction products. ... -
Replacement of saturated with unsaturated fats had no impact on vascular function but beneficial effects on lipid biomarkers, E-selectin, and blood pressure results from the randomized, controlled Dietary Intervention and VAScular function (DIVAS) study
Vafeiadou, Katerina; Weech, Michelle; Altowaijri, Hana; Todd, Sue; Yaqoob, Parveen; Jackson, Kim G.; Lovegrove, Julie A. (2015-07-31)BACKGROUND: Public health strategies to lower cardiovascular disease (CVD) risk involve reducing dietary saturated fatty acid (SFA) intake to ≤10% of total energy (%TE). However, the optimal type of replacement fat is ... -
A review of the evidence for the effects of total dietary fat, saturated, monounsaturated and n-6 polyunsaturated fatty acids on vascular function, endothelial progenitor cells and microparticles
Vafeiadou, Katerina; Weech, Michelle; Sharma, Vandana; Yaqoob, Parveen; Todd, Susan; Williams, Christine M.; Jackson, Kim G.; Lovegrove, Julie A. (2012-02)Vascular dysfunction is recognised as an integrative marker of CVD. While dietary strategies aimed at reducing CVD risk include reductions in the intake of SFA, there are currently no clear guidelines on what should replace ... -
Soy isoflavones increase preprandial peptide YY (PYY), but have no effect on ghrelin and body weight in healthy postmenopausal women
Weickert, Martin O.; Reimann, Manja; Otto, Bärbel; Hall, Wendy L.; Vafeiadou, Katerina; Hallund, Jesper; Ferrari, Marika; Talbot, Duncan; Branca, Francesco; Bügel, Susanne; Williams, Christine M; Zunft, Hans-Joachim; Koebnick, Corinna (2006)Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) and ghrelin, ... -
Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women : interactions with genotype and equol production
Hall, Wendy L.; Vafeiadou, Katerina; Hallund, Jesper; Bügel, Susanne; Koebnick, Corinna; Reimann, Manja; Ferrari, Marika; Branca, Francesco; Talbot, Duncan; Dadd, Tony; Nilsson, Maria; Dahlman-Wright, Karin; Gustafsson, Jan-Ake; Minihane, Anne-Marie; Williams, Christine M. (2005-12)Dietary isoflavones are thought to be cardioprotective because of their structural similarity to estrogen. The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by ... -
Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women : interactions with genotype and equol production
Hall, Wendy L.; Vafeiadou, Katerina; Hallund, Jesper; Bugel, Susanne; Reimann, Manja; Koebnick, Corinna; Zunft, H-J. Franz; Ferrari, Marika; Branca, Francesco; Dadd, Tony; Talbot, Duncan; Powell, Jonathan; Minihane, Anne-Marie; Cassidy, Aedin; Nilsson, Maria; Dahlman-Wright, Karin; Gustafsson, Jan-Ake; Williams, Christine M. (2006-03)The hypocholesterolemic effects of soy foods are well established, and it has been suggested that isoflavones are responsible for this effect. However, beneficial effects of isolated isoflavones on lipid biomarkers of ... -
Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes
Vauzour, David; Buonfiglio, Maria; Corona, Giulia; Chirafisi, Joselita; Vafeiadou, Katerina; Angeloni, Cristina; Hrelia, Silvana; Hrelia, Patrizia; Spencer, Jeremy P. E. (2010-04)The degeneration of dopaminergic neurons in the substantia nigra has been linked to the formation of the endogenous neurotoxin 5-S-cysteinyl-dopamine. Sulforaphane (SFN), an isothiocyanate derived from the corresponding ...