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Browsing University of Hertfordshire by Author "Dunnett, S.B."
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Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation
Murphy, K. P. S. J.; Carter, R. J.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J.; Lione, Lisa (2000-07-01)Huntington's disease (HD) is an autosomal dominant progressive and fatal neurodegenerative brain disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the gene. Presymptomatic Huntington's disease ... -
Behavioural analysis of unilateral monoamine depletion in the marmoset
Annett, L.E.; Rogers, D.C.; Henandez, T.D.; Dunnett, S.B. (1992)Unilateral stereotaxic injections of 6-hydroxydopamine (6-OHDA) into the nigrostriatal bundle of marmosets (Callithrix jacchus) produced substantial losses of tyrosine hydroxylase immunoreactive neurons from the substantia ... -
Behavioural assessment of the effects of embryonic nigral grafts in marmosets with unilateral OHDA lesions of the nigrostriatal pathway
Annett, L.E.; Martel, F.L.; Rogers, D.C.; Ridley, R. M.; Baker, H. F.; Dunnett, S.B. (1994)Grafts of embryonic nigral tissue were made into the striatum of marmosets (Callithrix jacchus) which had previously received a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal bundle. The grafts comprised ... -
Behavioural effects of subthalmic nucleus lesions in the hemiparkinsonian marmoset.(Callithrix jacchus)
Henderson, J.M.; Annett, L.E.; Torres, E.M.; Dunnett, S.B. (1998)Recent studies in non-human primates support a role for the subthalamic nucleus in the expression of parkinsonian symptomatology, and it has been proposed that subthalamic lesions may provide a surgical treatment for the ... -
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
Lione, Lisa; Carter, R. J.; Humby, T.; Mangiarini, L.; Mahal, A.; Bates, G. P.; Dunnett, S.B.; Morton, A. J. (1999-04-15)Transgenic mice expressing exon 1 of the human Huntington's disease (HD) gene carrying a 141-157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have ... -
A comparison of the behavioural effects of embryonic nigral grafts in the caudate nucleus and in the putamen of marmosets with unilateral 6-OHDA lesions
Annett, L.E.; Torres, E.M.; Ridley, R. M.; Baker, H. F.; Dunnett, S.B. (1995)The behaviour of marmosets with unilateral 6-hydroxydopamine lesions of the nigrostriatal bundle and grafts of embryonic mesencephalon in either the caudate nucleus or the putamen was compared with that of lesion-alone and ... -
Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat
Henderson, J.M.; Annett, L.E.; Ryan, L.; Chiang, W.; Hidaka, S.; Torres, E.M.; Dunnett, S.B. (1999)Lesions of the subthalamic nucleus can restore some imbalances in motor output of the basal ganglia induced by nigrostriatal dopamine depletion, and have been proposed as a potential therapy for Parkinson’s disease. Although ...