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Browsing University of Hertfordshire by Author "Gutkin, Boris"
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Endogenous cholinergic inputs and local circuit mechanisms govern the phasic mesolimbic dopamine response to nicotine
Graupner, Michael; Maex, Reinoud; Gutkin, Boris (2013-08-15)Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA). Recent data have led to a debate about the principal ... -
Temporal integration and 1/f power scaling in a circuit model of cerebellar interneurons
Maex, Reinoud; Gutkin, Boris (2017-07-01)Inhibitory interneurons interconnected via electrical and chemical (GABAA receptor) synapses form extensive circuits in several brain regions. They are thought to be involved in timing and synchronization through fast ... -
Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens
Maex, Reinoud; Grinevich, Vladimir P; Grinevich, Valentina; Budygin, Evgeny; Bencherif, Merouane; Gutkin, Boris (2014-08-22)Neuronal nicotinic acetylcholine receptors (NNRs) of the α7 subtype have been shown to contribute to the release of dopamine in the nucleus accumbens. The site of action and the underlying mechanism, however, are unclear. ...