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Browsing University of Hertfordshire by Author "Moreno, L."
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Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses
Sanchez Bruni, S. F.; Fusé, L.A.; Moreno, L.; Saumell, C.A.; Alvarez, L.I.; Fiel, C.; McKellar, Quintin; Lanusse, C.E. (2005-05)Reasons for performing the study: The study of novel pharmacological strategies to control parasitism in horses is required since many parasite species have developed resistance to anthelmintic drugs.Objectives: To evaluate ... -
COX-1, and not COX-2 activity, regulates airway function : Relevance to aspirin-sensitive asthma
Harrington, L.S.; Lucas, R.; McMaster, S.K.; Moreno, L.; Scadding, G.; Mitchell, J.A.; Warner, T.D. (2008-11-01)Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 ... -
Homeostatic role of toll-like receptor 4 in the endothelium and heart
Harrington, L.S.; Belcher, E.; Moreno, L.; Mitchell, J.A.; Carrier, M.J. (2007-12)Toll-like receptor 4 (TLR4) is a pattern recognition receptor for lipopolysaccharide from Gram negative bacteria and thus is integral to the innate immune response in mammals. In addition, TLR4 is associated with atherosclerosis ... -
Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells : Comparison with Toll-like receptor 4 responses in macrophages
Moreno, L.; McMaster, S.K.; Gatheral, T.; Bailey, L.; Harrington, L.; Cartwright, N.; Armstrong, P.C.J.; Warner, T.D.; Paul-Clark, M.; Mitchell, J.A. (2010-08)Background and purpose: Gram-negative bacteria contain ligands for Toll-like receptor (TLR) 4 and nucleotide oligomerization domain (NOD) 1 receptors. Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products ... -
Pharmacology of airways and vessels in lung slices in situ : Role of endogenous dilator hormones
Moreno, L.; Perez-Vizcaino, F.; Harrington, L.; Faro, R.; Sturton, G.; Barnes, P.J.; Mitchell, J.A. (2006-08-21)Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and ... -
The PPAR target gene CD36 is a rate limiting factor for the sensing of gram positive S-aureus in vascular smooth muscle cells but not in macrophages
Moreno, L.; McMaster, S.K.; Paul-Clark, M.; MacKenzie, Louise Susan; Cartwright, N.; Secher, T.; Quesniaux, V.; Ryffel, B.; Mitchell, J.A. (2008-08-01)Bacteria activate macrophages and vascular smooth muscle cells (VSMCs) resulting in induction of nitric oxide synthase (NOS)II activity. Here we show that the PPARc agonist rosiglitazone (rosi) increases the sensing of ... -
The PPARβ/δagonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension
Harrington, L.S.; Moreno, L.; Reed, A.; Mitchell, J.A.; Wort, S.J.; Desvergne, B.; Garland, C.; Zhao, L. (2010-03-04)Background: Pulmonary vascular diseases are increasingly recognised as important clinical conditions. Pulmonary hypertension associated with a range of aetiologies is difficult to treat and associated with progressive ... -
Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium
Mitchell, J.A.; Ali, F.; Bailey, L.; Moreno, L.; Harrington, L.S. (2008-01)The endothelium lines the luminal surface of every blood vessel, allowing it contact with circulating blood elements, as well as the underlying vascular smooth muscle layer. In healthy vessels, the endothelium expresses ...