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Browsing University of Hertfordshire by Author "Skaper, S.D."
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Amyloid β-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures
Fonfria, E.; Marshall, I.C.B.; Boyfield, I.; Skaper, S.D.; Hughes, J.P.; Owen, D.; Zhang, W.; Miller, B.A.; Benham, C.D.; McNulty, S. (2005)Amyloid β-peptide (Aβ) is the main component of senile plaques which characterize Alzheimer's disease and may induce neuronal death through mechanisms which include oxidative stress. To date, the signalling pathways linking ... -
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase
Fonfria, E.; Marshall, I.C.B.; Benham, C.D.; Boyfield, I.; Brown, J.D.; Hill, K.; Hughes, J.P.; Kelsell, R.E.; Skaper, S.D.; Scharenberg, A.M.; McNulty, S. (2004) -
TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia
Fonfria, E.; Mattei, C.; Hill, K.; Brown, J.T.; Randall, A.D.; Benham, C.D.; Skaper, S.D.; Campbell, C.A.; Crook, B.; Murdoch, P.R.; Wilson, J.M.; Murio, F.P.; Owen, D.; Tilling, P.L.; McNulty, S. (2006)We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle ...