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Browsing University of Hertfordshire by Author "Srinivasan, Manivannan"
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Apixaban Enhances Endogenous Fibrinolysis in Patients with Atrial Fibrillation
Spinthakis, Nikolaos; Gue, Ying X.; Farag, Mohamed; Srinivasan, Manivannan; Wellsted, David; Lip, Gregory Y H; Arachchillage, Deepa RJ; Gorog, Diana (2019-09-01)AIMS: Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which strongly relates to improved functional outcome. The impact of oral anticoagulants ... -
Impact of Preadmission Morphine on Reinfarction in Patients With ST-Elevation Myocardial Infarction Treated With Percutaneous Coronary Intervention : A Meta-Analysis
Gue, Ying; Spinthakis, Nikolaos; Farag, Mohamed; Kubica, Jacek; Siller-Matula, Jolanta M; Srinivasan, Manivannan; Gorog, Diana (2020-01-28)Opiates are the traditional analgesics used in patients with ST-elevation myocardial infarction (STEMI). Pharmacodynamic studies indicate that opiates delay the absorption of orally administered P2Y 12 inhibitors and the ... -
Impaired endogenous fibrinolysis at high shear using a point-of-care test in STEMI is associated with alterations in clot architecture
Spinthakis, Nikolaos; Gue, Ying; Farag, Mohamed; Ren, Guogang; Srinivasan, Manivannan; Baydoun, Anwar; Gorog, Diana A (2019-04-01)Impaired endogenous fibrinolysis is an adverse prognostic biomarker in acute coronary syndrome (ACS). Abnormally dense in vitro fibrin thrombi have been demonstrated in ACS patients and related to hypofibrinolysis using ... -
Impaired endogenous fibrinolysis in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention is a predictor of recurrent cardiovascular events : the RISK PPCI study
Farag, Mohamed; Spinthakis, Nikolaos; Gue, Ying X.; Srinivasan, Manivannan; Sullivan, Keith; Wellsted, David; Gorog, Diana A. (2019-01-14)Aims: The endogenous fibrinolytic system serves to prevent lasting thrombotic occlusion and infarction following initiation of coronary thrombosis. We aimed to determine whether impaired endogenous fibrinolysis can identify ... -
Morphine Analgesia Pre-PPCI Is Associated with Prothrombotic State, Reduced Spontaneous Reperfusion and Greater Infarct Size
Farag, Mohamed; Spinthakis, Nikolaos; Srinivasan, Manivannan; Sullivan, Keith; Wellsted, David; Gorog, Diana A (2018-03-01)The emergency management of ST-elevation myocardial infarction (STEMI) involves treatment with dual-antiplatelet therapy (DAPT) and primary percutaneous coronary intervention (PPCI). Pain is generally treated with opiates, ... -
Percutaneous coronary intervention with drug-eluting stent versus coronary artery bypass grafting : A meta-analysis of patients with left main coronary artery disease
Spinthakis, Nikolaos; Farag, Mohamed; Gorog, Diana A; Prasad, Abhiram; Mahmood, Hamid; Gue, Ying; Wellsted, David; Nabhan, Ashraf; Srinivasan, Manivannan (2017-12-15)BACKGROUND: The relative efficacy and safety of percutaneous coronary intervention (PCI) with drug-eluting stents (DES), in comparison to coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) ... -
Rationale and design of "Can Very Low Dose Rivaroxaban (VLDR) in addition to dual antiplatelet therapy improve thrombotic status in acute coronary syndrome (VaLiDate-R)" study : A randomised trial modulating endogenous fibrinolysis in patients with acute coronary syndrome
Gue, Ying X; Kanji, Rahim; Wellsted, David M; Srinivasan, Manivannan; Wyatt, Solange; Gorog, Diana A (2019-12-23)Impaired endogenous fibrinolysis is novel biomarker that can identify patients with ACS at increased cardiovascular risk. The addition of Very Low Dose Rivaroxaban (VLDR) to dual antiplatelet therapy has been shown to ... -
Relationship of platelet reactivity and inflammatory markers to recurrent adverse events in patients with ST-elevation myocardial infarction
Adatia, Krishma; Farag, Mohamed; Gue, Ying X.; Srinivasan, Manivannan; Gorog, Diana (2019-10-30)Background Patients with ST-elevation myocardial infarction (STEMI) exhibit pro-thrombotic and pro-inflammatory states. Markers of enhanced platelet reactivity and inflammation are predictive of adverse outcome. However, ... -
Relative effects of different non-vitamin K antagonist oral anticoagulants on global thrombotic status in atrial fibrillation
Farag, Mohamed; Niespialowska-Steuden, Maria; Okafor, Osita; Artman, Benjamin; Srinivasan, Manivannan; Khan, Arif; Sullivan, Keith; Wellsted, David; Gorog, Diana A (2016-10-02)Non-vitamin K antagonist oral anticoagulants (NOACs) reduce the risk of thromboembolism in patients with atrial fibrillation (AF). There has been no head-to-head comparison of the effect of these agents on ex vivo thrombotic ... -
Use of bioresorbable vascular scaffold : a meta-analysis of patients with coronary artery disease
Farag, Mohamed; Spinthakis, Nikolaos; Gorog, Diana A; Prasad, Abhiram; Sullivan, Keith; Akhtar, Zaki; Kukreja, Neville; Srinivasan, Manivannan (2016-08-26)BACKGROUND: Differences in outcomes between bioresorbable vascular scaffold (BVS) systems and drug-eluting metal stents (DES) have not been fully evaluated. We aimed to compare clinical and angiographic outcomes in randomised ...