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Browsing University of Hertfordshire by Author "Thompson, C."
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The complexation between novel comb shaped amphiphilic polyallylamine and insulin : towards oral insulin delivery
Thompson, C.; Tetley, L.; Uchegbu, I.F.; Cheng, W.P. (2009)Novel amphiphilic polyallylamine (PAA) were previously synthesised by randomly grafting palmitoyl pendant groups and subsequent quaternising with methyl iodide. The ability of these self-assembled polymers to spontaneously ... -
In vitro and in vivo characterisation of a novel peptide delivery system : Amphiphilic polyelectrolyte–salmon calcitonin nanocomplexes
Cheng, W.P.; Thompson, C.; Ryan, S.M.; Aguirre, T.; Tetley, L.; Brayden, D.J. (2010)The cationic peptide, salmon calcitonin (sCT) was complexed with the cationic amphiphilic polyelectrolyte, poly(allyl)amine, grafted with palmitoyl and quaternary ammonium moieties at pH 5.0 and 7.4 to yield particulates ... -
Uptake and transport of novel amphiphilic polyelectrolyte-insulin nanocomplexes by caco-2 cells - towards oral insulin
Thompson, C.; Cheng, W.P.; Gadad, P.; Skene, K.; Smith, M.; Smith, G.; McKinnon, A.; Knott, R. (2011)Purpose: The influence of polymer architecture on cellular uptake and transport across Caco-2 cells of novel amphiphilic polyelectrolyte-insulin nanocomplexes was investigated. Method: Polyallylamine (PAA) (15 kDa) was ...