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Browsing University of Hertfordshire by Author "Upton, Neil"
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Ketamine supresses REM sleep and markedly increases EEG gamma oscillations in the Wistar Kyoto rat model of treatment-resistant depression
Kantor, Sandor; Lanigan, Michael; Giggins, Lauren; Lione, Lisa; Magomedova, Lilia; de Lannoy, Inés; Upton, Neil; Duxon, Mark (2023-07-09)Wistar–Kyoto (WKY) rats exhibit depression-like characteristics and decreased sensitivity to monoamine-based antidepressants, making them a suitable model of treatment-resistant depression (TRD). Ketamine has emerged ... -
Preclinical Neuropathic Pain Assessment; the Importance of Translatability and Bidirectional Research : Translatable and Bidirectional Research
Fisher, Amy; Lanigan, Michael; Upton, Neil; Lione, Lisa (2021-02-08)For patients suffering with chronic neuropathic pain the need for suitable novel therapies is imperative. Over recent years a contributing factor for the lack of development of new analgesics for neuropathic pain has been ... -
The streptozocin model of diabetes induces neuropathic pain, anhedonia and impaired burrowing in rats
Fisher, Amy; Kennard, Polly; Upton, Neil; Lione, Lisa (2015-12-16)Many diabetic patients experience chronic neuropathic pain leading to a reduced quality of life which poses a huge economic burden to the health system and society. There is a dire need to develop more efficacious analgesics ...