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Pharmacodynamics and pharmacokinetics of tolfenamicacid in ruminating calves: Evaluation in models of acute inflammation
(1998-05)
Injections of mild irritants intradermally (carrageenan, zymosan and dextran) and intracaveally (carrageenan)in a tissue cage model of inflammation were used in studies of the pharmacodynamics and pharmacokinetics of ...
Stereospecific pharmacodynamics and pharmacokinetics of carprofen in the dog
(1994-12)
The non-steroidal anti-inflammatory drug (NSAID) carprofen (CPF) contains a single chiral centre. It was administered orally to Beagle dogs as a racemate (rac-CPF) at a dose of 4 mg per kg body weight and as individual ...
Pharmacodynamics and pharmacokinetics of carprofen in the horse.
(1994-05)
The pharmacokinetics and pharmacodynamics of the nonsteroidal anti-inflammatory drug (NSAID) carprofen have been evaluated in 6 horses using a model of acute non-immune inflammation. Following intravenous administration ...
Pharmacodynamics of tolfenamic acid in dogs : Evaluation of dose response relationships
(1994-03-03)
Tolfenamic acid was administered to beagle dogs at 2, 4 and 8 mg/kg bodyweight i.m. and the concentration of drug in plasma and in inflamed (administered carrageenan) and non-inflamed subcutaneous tissue cage fluid was ...
Pharmacology and therapeutics of non-steroidal anti-inflammatory drugs in the dog and cat 2 : Individual agents
(1991)
The general pharmacology of the non-steroidal anti-inflammatory drugs (NSAIDs) used in dogs and cats has been described in part 1 of this review (Lees and others 1991). This paper outlines the properties of the individual ...
Pharmacology and therapeutics of nonsteroidal antiinflammatory drugs in the dog and cat 1 : General pharmacology
(1991)
The inflammatory process is described with particular reference to the cardinal signs, the microcir-culatory changes and the mediators and modulators of inflammation. Mediators and modulars comprise targets for therapeutic ...
Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog
(1990)
The non-steroidal anti-inflammatory drug (NSAID) carprofen was administered to dogs as a mixed-micelle solution at a dose rate of 0–7 mg/kg intravenously, as a palatable paste at a dose rate of 0–7 mg/kg orally, and as an ...