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GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
(2015-12-01)
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 ...
Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction : role of vorapaxar
(2015-07-22)
Acute myocardial infarction (AMI) is generally attributed to coronary atherothrombotic disease. Platelet activation is essential for thrombus formation and is thus an important target for pharmacological intervention to ...
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
(2015-05-28)
Quercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of ...
Decoding odor quality and intensity in the Drosophila brain
(2014-12-16)
To internally reflect the sensory environment, animals create neural maps encoding the external stimulus space. From that primary neural code relevant information has to be extracted for accurate navigation. We analyzed ...
Automatic segmentation of odor maps in the mouse olfactory bulb using regularized non-negative matrix factorization
(2014-09-01)
Segmentation of functional parts in image series of functional activity is a common problem in neuroscience. Here we apply regularized non-negative matrix factorization (rNMF) to extract glomeruli in intrinsic optical ...
Incretin-modulated beta cell energetics in intact islets of Langerhans
(2014-06-01)
Incretins such as glucagon-like peptide 1 (GLP-1) are released from the gut and potentiate insulin release in a glucose-dependent manner. Although this action is generally believed to hinge on cAMP and protein kinase A ...
The Green's function formalism as a bridge between single- and multi-compartmental modeling
(2013-12)
Neurons are spatially extended structures that receive and process inputs on their dendrites. It is generally accepted that neuronal computations arise from the active integration of synaptic inputs along a dendrite between ...
Peptide pills for brain diseases? : Reality and future perspectives
(2013-04)
The peptide therapeutic market is one of the fastest growth areas of the pharmaceutical industry. Although few orally administered peptides are marketed and many are in different phases of clinical development, there is ...
In vivo decontamination of the nerve agent VX using the domestic swine model
(2012-11)
The purpose of this in vivo study was to assess a new, putatively optimised method for mass casualty decontamination ("ORCHIDS protocol") for effectiveness in removing the chemical warfare agent VX from the skin of ...