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Tissue transglutaminase (TG-2) modified amniotic membrane : a novel scaffold for biomedical applications
(2012-08)
The amniotic membrane (AM) is considered as a natural cell culture substrate and has occasionally been exploited in regenerative medicine especially for ocular surface reconstruction and dermal wound healing applications. ...
Neuroinflammation : modulation by flavonoids and mechanisms of action
(2012-02)
Neuroinflammatory processes are known to contribute to the cascade of events culminating in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's and Alzheimer's disease. Recently, there has ...
The generation of phase differences and frequency changes in a network model of inferior olive subthreshold oscillations
(2012)
It is commonly accepted that the Inferior Olive (IO) provides a timing signal to the cerebellum. Stable subthreshold oscillations in the IO can facilitate accurate timing by phase-locking spikes to the peaks of the ...
Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1
(2011-11-16)
NCS-1 is a member of the neuronal calcium sensor (NCS) family of EF-hand Ca(2+) binding proteins which has been implicated in several physiological functions including regulation of neurotransmitter release, membrane ...
The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus
(2011-11)
Some isolates of the opportunistic human pathogenic fungus Aspergillus fumigatus are known to be infected with mycoviruses. The dsRNA genomes of two of these mycoviruses, which include a chrysovirus and a partitivirus, ...
Receptive field optimisation and supervision of a fuzzy spiking neural network
(2011-04)
This paper presents a supervised training algorithm that implements fuzzy reasoning on a spiking neural network. Neuron selectivity is facilitated using receptive fields that enable individual neurons to be responsive to ...
Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development
(2011-01-18)
Laboratory animals are often used in drug delivery and research. However, basic information about their gastrointestinal pH, fluid volume, and lymphoid tissue is not completely known. We have investigated these post-mortem ...
Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol
(2010-06)
The olive oil polyphenol, hydroxytyrosol (HT), is believed to be capable of exerting protection against oxidative kidney injury. In this study we have investigated the ability of HT and its O-methylated metabolite, ...
Sustained performance by red and white muscle fibres from the dogfish Scyliorhinus canicula
(2010-06-01)
The mechanical performance of red and white muscle fibres from dogfish was compared during a long series of contractions with sinusoidal movement or under isometric conditions at 12 degrees C (normal in vivo temperature). ...
Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes
(2010-04)
The degeneration of dopaminergic neurons in the substantia nigra has been linked to the formation of the endogenous neurotoxin 5-S-cysteinyl-dopamine. Sulforaphane (SFN), an isothiocyanate derived from the corresponding ...