Now showing items 61-70 of 356
An investigation into solvent-membrane interactions when assessing drug release from organic vehicles using regenerated cellulose membranes
The influence of organic solvents on artificial membranes when assessing drug release from topical formulations is, generally, poorly characterised yet current guidelines require no characterisation of the membrane before, ...
Effect of propylene glycol on in vitro membrane transport of ionized diclofenac diethylamine from saturated binary cosolvent mixtures
For saturated formulations, where thermodynamic activity () is equal to 1, the flux of the permeant through a membrane should theoretically be constant irrespective of the delivery vehicle (Higuchi 1960). Although some ...
The effect of temperature on the diffusion of lidocaine base
The inherent barrier properties of the skin present a major problem for the transdermal delivery of drugs. Due to the selectively permeable nature of the skin compounds need to be relatively lipophilic with a molecular ...
The effect of complex coordination on gallium determination using ion chromatography
Interest in the therapeutic use of gallium is increasing due to the discovery of its effectiveness as an anti-tumour and anti-microbial agent (Bernstein 1998). However, gallium strongly coordinates with many organic and ...
Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1 : implications for Parkinson's disease and protection by polyphenols
Mechanisms of nigral cell injury in Parkinson's disease remain unclear, although a combination of increased oxidative stress, the formation of catecholamine-quinones and the subsequent formation of neurotoxic cysteinyl-c ...