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A simple formulation of microtubule dynamics: quantitative implications of the dynamic instability of microtubule
(1989)
A simple formulation of microtubule dynamic instability is presented, which is based on the experimental observations by T. Horio and H. Hotani of coexisting, interconverting growing and shrinking microtubules. Employing ...
A Lateral Cap model of microtubule dynamic instability
(1989)
The co-existence and interconversion of growing and shrinking microtubules have been termed ‘dynamic instability’, and have been directly observed to occur under a variety of conditions in vitro and in vivo. Previous ...
The effect of podophyllotoxin on microtubule dynamics
(1989)
We have investigated the effects of podophyllotoxin on the dynamic properties of microtubules assembled from pure tubulin dimer. Excess podophyllotoxin causes the complete disassembly of microtubules, through formation of ...