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The electrostability and electrically assisted delivery of an organophosphate pretreatment (physostigmine) across human skin in vitro
Physostigmine is a tertiary carbamate that is utilised as a pretreatment against organophosphate intoxication. Oral delivery of physostigmine is not practical due to high first pass metabolism and short Elimination half ...
Non-invasive quantification of skin injury resulting from exposure to sulphur mustard and Lewisite vapours
The severity and progression of skin lesions resulting from exposure to the chemical warfare agents Lewisite (L) and sulphur mustard (SM) have been investigated using the non-invasive biophysical methods of evaporimetry ...
Biophysical measurements of human forearm, skin in vivo : effects of site, gender, chirality and time
Background/aims: Measurements of transepidermal water loss (TEWL) and skin colour are biophysical techniques commonly used to measure the in vivo skin effects of cosmetics, topical medicaments and chemical irritants. The ...
Dermabrasion - a novel concept in the surgical management of sulphur mustard injuries
Since its first use on the battlefields of Northern France during the First World War (1914-1918), sulphur mustard has remained a significant chemical threat to military forces around the world. Progress towards an effective ...
Human skin absorption of bis-2-(chloroethyl)sulphide (sulphur mustard) in vitro
The purpose of this study was to measure the absorption and intra-epidermal fate of S-35-radiolabelled sulphur mustard ((SM)-S-35) in human breast skin in vitro. Skin (full-thickness or heat-separated epidermis) was placed ...