Now showing items 1-6 of 6
Stabilisation of deoxyribonuclease in hydrofluoroalkanes using miscible vinyl polymers
A mix of biocompatible macromolecules (poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP)) has been shown previously to enhance the physical stability of non-aqueous pharmaceutical suspensions. The aim of this ...
Schistosome cercarial interactions with human keratinocytes and langerhans cells
The human parasite, Schistosoma mansoni is known to modulate host immune responses in order to promote its own survival. However, studies investigating the interaction between the skin-invading cercarial stage and cells ...
In-vitro and in-vivo studies on a topical formulation of sitamaquine dihydrochloride for cutaneous leishmaniasis
The efficacy of topical formulations of the 8-aminoquinoline, sitamaquine dihydrochloride, in both in-vitro and in in-vivo models of cutaneous leishmaniasis is reported. In-vitro parasite assays confirmed that sitamaquine ...
Hyaluronan: Investigations into the mode of action of hyaluronan in topical drug delivery
(American Chemical Society, 2006)
Hyaluronan (HA) is a polyanionic, polysaccharide ubiquitous in mammals where it has a protective, structure stabilising and shock-absorbing role. The unique viscoelastic nature of HA along with its biocompatibility and ...
Dermal and transdermal drug delivery systems : Current and future prospects
The protective function of human skin imposes physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have adequate lipophilicity and ...