Now showing items 1-3 of 3
The application of Gaussian processes in the prediction of percutaneous absorption
Objectives The aim was to assess mathematically the nature of a skin permeability dataset and to determine the utility of Gaussian processes in developing a predictive model for skin permeability, comparing it with existing ...
Transient drug supersaturation kinetics of beclomethasone dipropionate in rapidly drying films
Supersaturation is an effective method to enhance the delivery of active compounds into the skin, however the long-term instability of the drug in these formulations that exceed thermodynamic unity prevents clinical use. ...
Overcoming the nail barrier : A systematic investigation of ungual chemical penetration enhancement
This study investigated the in vitro nail permeability of penetrants of varying lipophilicity—caffeine (CF, log P −0.07), methylparaben (MP, log P 1.96) and terbinafine (TBF, log P 3.3) and the effect of 2 novel penetration ...