Now showing items 1-10 of 70
Not so EEZE : the ‘EDHF’ antagonist 14, 15 Epoxyeicosa-5(z)-enoic Acid has vasodilator properties in mesenteric arteries
P-450 metabolites, including the epoxyeicosatrienoic acids, are likely candidates for endothelial derived hyperpolarising factor (EDHF). In the present study, we confirm that the stable analogue 11-nonyloxyundec-8(Z)-enoic ...
Development of a decision support system for phoma and light leaf spot in winter oilseed rape (PASSWORD project)
Pests and diseases in winter oilseed rape cause serious loss of yield and quality. Losses, predominantly from diseases, are estimated to exceed £80 million/annum in some years. These losses have occurred despite an annual ...
Role of inducible nitric oxide synthase in N-methyl-D-aspartic acid-induced strio-nigral degeneration
N-Methyl-D-aspartate (NMDA)-induced striatal excitotoxicity is mediated by nitric oxide (NO) but the role of inflammatory mechanisms and inducible nitric oxide synthase (iNOS) induction is not clear. Unilateral intrastriatal ...
Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms
We have investigated the ability of pramipexole, a dopamine agonist used in the symptomatic treatment of Parkinson's disease (PD), to protect against cell death induced by 1-methyl-4-phenylpyridinium (MPP+) and rotenone ...
The new CCP4 Coordinate Library as a toolkit for the design of coordinate-related applications in protein crystallography
The new CCP4 Coordinate Library is a development aiming to provide a common layer of coordinate-related functionality to the existing applications in the CCP4 suite, as well as a variety of tools that can simplify the ...
Predicting light leaf spot (Pyrenopeziza brassicae) risk on winter oilseed rape (Brassica napus) in England and Wales, using survey, weather and crop information
Data from surveys of winter oilseed rape crops in England and Wales in growing seasons with harvests in 1987-99 were used to construct statistical models to predict, in autumn (October), the incidence of light leaf spot ...
Novel role for P2X receptor activation in endothelium-dependent vasodilation
ATP is an important vasoactive mediator, which acts via two receptor classes: P2X and P2Y. Activation of P2X receptors has traditionally been associated with the well-characterised vasoconstrictor properties of ATP. In the ...
Oxalate production by Sclerotinia sclerotiorum deregulates guard cells during infection.
Oxalic acid is a virulence factor of several phytopathogenic fungi, including Sclerotinia sclerotiorum (Lib.) de Bary, but the detailed mechanisms by which oxalic acid affects host cells and tissues are not understood. We ...
Developmental signals in skin morphogenesis
Effect of molecular weight and concentration hyaluronan on the in-vitro release characteristics of ibuprofen and diclofenac sodium across cellulose membrane
Hyaluronan (HA) is a naturally occurring polyanionic glycosaminoglycan. Drugs formulated in HA and applied topically are retained in the skin with little systemic absorption (Brown et al 2000, 2001). However, the precise ...