Browsing Research publications by Author "Hunter, A.J."
Now showing items 1-6 of 6
-
Characterisation of SB-221420-A, a neuronal Ca and Na channel antagonist in experimental models of stroke
Campbell, C.A.; Barone, F.C.; Benham, C.D.; Hadingham, S.J.; Harries, M.; Hills, J.M.; Lewis, V.A.; Parsons, A.A.; White, R.F.; Hunter, A.J. (2000) -
The effects of SB 206284A, a novel neuronal Ca channel antagonist in models of cerebral ischaemia
Wood, N.; Barone, F.C.; Benham, C.D.; Brown, T.H.; Campbell, C.A.; Cooper, D.C.; Evans, M.L.; Feuerstein, G.; Hamilton, T.C.; Harries, M.; King, P.D.; Meakin, J.E.; Murkitt, J.L.; Patel, S.; Price, W.J.; Roberts, J.C.; Rothaul, A.L.; Samson, N.A.; Smith, S.J.; Hunter, A.J. (1997)The effects of SB 206284A, 1-[7-(4-benzyloxyphenoxy)heptyl] piperidine hydrochloride, have been investigated in vitro on calcium and sodium currents in rat-cultured dorsal root ganglion (DRG) neurones and potassium-mediated ... -
Furosemide inhibits regenerative cortical spreading depression in anaesthetised cats
Read, S.J.; Smith, M.I.; Benham, C.D.; Hunter, A.J.; Parsons, A.A. (1997)Ionic perturbations occur during cortical spreading depression (SD), a phenomenon implicated in migraine pathophysiology. We studied the effect of 0.2,2 and 20 mg kg-1 iv (n=4) furosemide on cortical direct current (d.c.) ... -
Orexin-A activates locus coeruleus cell firing and increases arousal in the rat
Hagan, J.J.; Leslie, R.A.; Patel, S.; Evans, M.L.; Wattam, T.A.; Holmes, S.; Benham, C.D.; Taylor, S.G.; Routledge, C.; Hemmati, P.; Munton, R.P.; Ashmeade, T.E.; Shah, A.S.; Hatcher, J.P.; Hatcher, P.D.; Jones, D.N.C.; Smith, M.I.; Piper, D.C.; Hunter, A.J.; Porter, R.A.; Upton, N. (1999) -
SB 201823-A antagonises calcium currents in central neurons and reduces the effects of focal ischaemia in rats and mice
Barone, F.C.; Lysko, P. G.; Price, W.J.; Feuerstein, G.; Benham, C.D.; Harrison, D. C.; Harries, M.; Bailey, S. J.; Hunter, A.J. (1995) -
SB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemia
Benham, C.D.; Brown, T.H.; Cooper, D.C.; Evans, M.L.; Harries, M.; Herdon, H.J.; Meakin, J.E.; Murkitt, K.L.; Patel, S.; Roberts, J.C.; Rothaul, A.L.; Smith, S.J.; Wood, N.; Hunter, A.J. (1993)We have characterised the Ca2+ channel blocking properties of a new non-peptide Ca2+ channel antagonist, SB 201823-A, in cultures of rat sensory neurones. The IC50 for SB 201823-A against total Ca2+ current in sensory ...