Browsing Research publications by Author "Tzortzis, George"
Now showing items 1-5 of 5
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CLSM method for the dynamic observation of pH change within polymer matrices for oral delivery
Cook, Michael T.; Saratoon, Teedah; Tzortzis, George; Edwards, Alexander; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2013-02-11)If acid-sensitive drugs or cells are administered orally, there is often a reduction in efficacy associated with gastric passage. Formulation into a polymer matrix is a potential method to improve their stability. The ... -
Layer-by-layer coating of alginate matrices with chitosan-alginate for the improved survival and targeted delivery of probiotic bacteria after oral administration
Cook, Michael T.; Tzortzis, George; Khutoryanskiy, Vitaliy V.; Charalampopoulos, Dimitris (2013-01-07)The oral administration of probiotic bacteria has shown potential in clinical trials for the alleviation of specific disorders of the gastrointestinal tract. However, cells must be alive in order to exert these benefits. ... -
Microencapsulation of a synbiotic into PLGA/alginate multiparticulate gels
Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2014-05-15)Probiotic bacteria have gained popularity as a defence against disorders of the bowel. However, the acid sensitivity of these cells results in a loss of viability during gastric passage and, consequently, a loss of efficacy. ... -
Microencapsulation of probiotics for gastrointestinal delivery
Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2012-08-20)The administration of probiotic bacteria as nutraceuticals is an area that has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. Many of the health promoting claims attributed ... -
Production and evaluation of dry alginate-chitosan microcapsules as an enteric delivery vehicle for probiotic bacteria
Cook, Michael T.; Tzortzis, George; Charalampopoulos, Dimitris; Khutoryanskiy, Vitaliy V. (2011-07-11)This study investigates the production of alginate microcapsules, which have been coated with the polysaccharide chitosan, and evaluates some of their properties with the intention of improving the gastrointestinal viability ...