Browsing Research publications by Author "Watt, A.P."

Now showing items 1-3 of 3

    • Identification of metabolites of a substance P (Neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma 

      Hop, C.E.C.A.; Wang, Y.; Kumar, S.; Elipe, M.V.S.; Raab, C.E.; Dean, D.C.; Poon, G.K.; Keohane, C.-A.; Strauss, J.; Chiu, S.-H.L.; Curtis, N.; Elliott, J.; Gerhard, U.; Locker, K.; Morrison, D.; Mortishire-Smith, R.; Thomas, S.; Watt, A.P.; Evans, D.C. (2002-01-01)
      [3R,5R,6S]-3-(2-cyclopropyloxy-5-trifluoromethoxyphenyl)-6-phenyl-1-oxa-7 -azaspiro[4.5]decane is a substance P (Neurokinin 1 receptor) antagonist. Substance P antagonists are proven in concept to have excellent potential ...

    • Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma 

      Hop, C.E.C.A.; Wang, Y.; Kumar, S.; Elipe, M.V.S.; Raab, C.E.; Dean, D.C.; Poon, G.K.; Keohane, C.-A.; Strauss, J.; Chiu, S.-H.L.; Curtis, N.; Elliott, J.; Gerhard, U.; Locker, K.; Morrison, D.; Mortishire-Smith, R.; Watt, A.P.; Evans, D.C. (2002-01-01)
      The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the ...

    • Metabolite identification in drug discovery 

      Watt, A.P.; Mortishire-Smith, R.J.; Gerhard, U.; Thomas, S.R. (2003-01-01)
      Recent developments in the technologies and approaches to identify metabolites in a drug discovery environment are reviewed. Samples may be generated using either in vitro systems - typically, but not exclusively, liver ...