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The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076
(1998-08-15)
ATP citrate (pro-S)-lyase (EC 4.1.3.8), a cytosolic enzyme that generates acetyl-CoA for cholesterol and fatty acid synthesis de novo, is a potential target for hypolipidaemic intervention. Here we describe the biological ...
Separation of immunomodulatory and cholesterol-lowering activities of heterocyclic azaspiranes
(1995-02-22)
Azaspiranes are novel immunomodulators which are effective in a variety of autoimmune diseases. One azaspirane analog, SK and F 105685 (N,N-dimethyl- 8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine dihydrochloride), ...