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Identification of metabolites of a substance P (Neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma
(2002-01-01)
[3R,5R,6S]-3-(2-cyclopropyloxy-5-trifluoromethoxyphenyl)-6-phenyl-1-oxa-7 -azaspiro[4.5]decane is a substance P (Neurokinin 1 receptor) antagonist. Substance P antagonists are proven in concept to have excellent potential ...
Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma
(2002-01-01)
The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the ...