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Antithrombotic in atrial fibrillation and coronary artery disease – Does less mean more?
(2022-06-15)
In the treatment of patients with chronic coronary syndrome, the use of antiplatelets in the form of aspirin is a class 1 indication in the prevention of future thrombotic events.1 Similarly, oral anticoagulation (OAC) has ...
Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: An European and Asia-Pacific Expert Consensus Paper
(2022-03-22)
Whilst there is a clear clinical benefit of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and venous thromboembolism (VTE) in reducing the risks of thromboembolism, major bleeding events (especially ...
Spontaneous reperfusion in patients with transient ST-elevation myocardial infarction - prevalence, importance and approaches to management
(2021-07-10)
Patients with transient ST-elevation myocardial infarction (STEMI) or spontaneous resolution (SpR) of the ST-segment elevation on electrocardiogram could potentially represent a unique group of patients posing a therapeutic ...
Fibrinolysis in platelet thrombi
(2021-05-12)
The extent and duration of occlusive thrombus formation following an arterial atherothrombotic plaque disruption may be determined by the effectiveness of endogenous fibrinolysis. The determinants of endogenous fibrinolysis ...
Assessment of endogenous fibrinolysis in clinical using novel tests - Ready for clinical roll-out?
(2021-04-01)
The occurrence of thrombotic complications, which can result in excess mortality and morbidity, represent an imbalance between the pro-thrombotic and fibrinolytic equilibrium.The mainstay treatment of these complications ...
Thrombotic complications in 2,928 patients with COVID-19 treated in intensive care: a systematic review
(2021-04-01)
A prothrombotic state is reported with severe COVID-19 infection, which can manifest in venous and arterial thrombotic events. Coagulopathy is reflective of more severe disease and anticoagulant thromboprophylaxis is ...
Precision treatment in ACS – role of assessing fibrinolysis
(2021-03-01)
Despite advancements in pharmacotherapy and interventional strategies, patients with acute coronary syndrome (ACS) remain at risk of recurrent thrombotic events. In addition to an enhanced tendency to thrombus formation, ...
Angiotensin Converting Enzyme 2 may mediate disease severity in COVID-19
(2020-06-09)
Identification of vulnerability to severe coronavirus disease 2019 (COVID-19) is extremely important and might allow optimised shielding and easing of lockdown. The disease is attributed to the severe acute respiratory ...
MINOCA presenting with STEMI- a review of incidence, aetiology, assessment and treatment
(2020-04-30)
Myocardial infarction with non-obstructive coronary artery (MINOCA) is a condition previously thought to be benign but has recently been shown to have comparable mortality to that of acute coronary syndrome with obstructive ...