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Endogenous fibrinolysis - relevance to clinical thrombosis risk assessment
(2020-12-09)
The development of an obstructive luminal thrombus is pathological and considered a failure of endogenous fibrinolysis. The consequences may be fatal, or result in lasting downstream organ damage. Therefore, assessment of ...
2-oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis
(2020-09-12)
Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous ...
Bioprosthetic valve thrombosis and degeneration following transcatheter aortic valve implantation (TAVI)
(2020-09-09)
Bioprosthetic valve thrombosis (BPVT) is a recognised complication of prosthetic aortic valves and can be seen in up to 13% of patients after transcatheter implantation.The mechanism of BPVT is not well known, abnormal ...
Reduction in ACE2 may mediate the prothrombotic phenotype in COVID-19
(2020-07-20)
This commentary refers to ‘Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy’, by R.M. Inciardi et al., doi: 10.1093/eurheartj/ehaa583.
Antithrombotic therapy in patients with atrial fibrillation and acute coronary syndrome
(2020-07-01)
Abstract: Acute coronary syndrome and atrial fibrillation are both common, and can occur in the same patient. Combination therapy with dual antiplatelet therapy and oral anticoagulation increases risk of bleeding. Where ...
Point-of-care Platelet Function Tests: Relevance to Arterial Thrombosis and Opportunities for Improvement
(2020-06-11)
Studies using whole blood platelet aggregometry as a laboratory research tool, provided important insights into the mecha- nism and modulators of platelet aggregation. Subsequently, a number of point-of-care (POC) platelet ...
Angiotensin Converting Enzyme 2 may mediate disease severity in COVID-19
(2020-06-09)
Identification of vulnerability to severe coronavirus disease 2019 (COVID-19) is extremely important and might allow optimised shielding and easing of lockdown. The disease is attributed to the severe acute respiratory ...
Usefulness of the NULL-PLEASE Score to predict 1 survival in out-of hospital cardiac arrest
(2020-05-07)
Purpose: Out-of-hospital cardiac arrest (OHCA) carries a very high mortality even after successful cardiopulmonary resuscitation. Currently, information given to relatives regarding prognosis following resuscitation is ...
MINOCA presenting with STEMI- a review of incidence, aetiology, assessment and treatment
(2020-04-30)
Myocardial infarction with non-obstructive coronary artery (MINOCA) is a condition previously thought to be benign but has recently been shown to have comparable mortality to that of acute coronary syndrome with obstructive ...