Now showing items 1-10 of 106
Detection of Newly Emerging Psychoactive Substances Using Raman Spectroscopy and Chemometrics
A novel approach for the identification of New Psychoactive Substances (NPS) by means of Raman spectroscopy coupled with Principal Components Analysis (PCA) employing the largest dataset of NPS reference materials to date ...
Octodrine: New Questions and Challenges in Sport Supplements
Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950’s, it has ...
Drowning in Diversity? A systematic way of clustering a representative set of new psychoactive substances
New psychoactive substances (NPS) can be generally described as a set of compounds that have been designed to mimic the effects of illegal recreational drugs, but are not subject to restriction or control with respect to ...
Rational design of novel fluorescent tagged glutamic acid dendrimers with different terminal groups and in-silico analysis of their properties
Dendrimers are hyperbranched polymers with a multifunctional architecture that can be tailored for the use in various biomedical applications. Peptide dendrimers are particularly relevant for drug delivery applications due ...
Intended and Unintended Use of Cathinone Mixtures
Introduction: Cathinones are one of the most popular categories of new psychoactive substances (NPS) consumed. Cathinones have different pharmacological activities and receptor selectivity for monoamine transporters based ...
Optimization of protein loaded PLGA nanoparticles manufacturing parameters following a quality-by-design approach
Development of a multivariate-based regression model for estimating the critical attributes for establishing a design-space for poly(lactic-co-glycolic acid) (PLGA) nanoparticles formulated by a double emulsion-solvent ...
Identification of excipient-protein interaction hotspots using computational approaches
Protein formulation development relies on the selection of excipients that inhibit protein-protein interactions preventing aggregation. Empirical strategies involve screening many excipient and buffer combinations using ...
Identification of new psychoactive substances using Raman spectroscopy: handheld and computational approaches.
(Research and Advances in Psychiatry, 2016-05)
At this conference, I gave a presentation on the identification of new psychoactive substances using handheld Raman spectroscopy and chemometrics.
Application of diffusion-edited and solvent suppression 1H NMR to the direct analysis of markers in valerian-hop liquid herbal products
The rising trend to consume herbal products for the treatment and/or prevention of minor ailments together with their chemical and pharmacological complexity means there is an urgent need to develop new approaches to their ...