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Bupropion perceived as a stimulant by two patients with a previous history of cocaine misuse
(2013-12)
Background and objective. Despite animal studies having shown a generalisation of the bupropion cue to cocaine, this drug has been used in cocaine abuse with mixed results. We here aimed at describing two cases which ...
The development of a 3D immunocompetent model of human skin
(2013-09)
As the first line of defence, skin is regularly exposed to a variety of biological, physical and chemical insults. Therefore, determining the skin sensitization potential of new chemicals is of paramount importance from ...
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
(2013-07-09)
There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, ...
Does the availability of snack foods in supermarkets vary internationally?
(2013-05-14)
Background Cross-country differences in dietary behaviours and obesity rates have been previously reported. Consumption of energy-dense snack foods and soft drinks are implicated as contributing to weight gain, however ...
Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis : experience in the ERAN inception cohort
(2013-05)
Outcomes in early Rheumatoid Arthritis (RA) may be improved by rapidly establishing a stable and effective disease modifying anti-rheumatic drug (DMARD) treatment regimen. We aimed to investigate whether baseline factors ...
Layer-by-layer coating of alginate matrices with chitosan-alginate for the improved survival and targeted delivery of probiotic bacteria after oral administration
(2013-01-07)
The oral administration of probiotic bacteria has shown potential in clinical trials for the alleviation of specific disorders of the gastrointestinal tract. However, cells must be alive in order to exert these benefits. ...
Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR) is involved in vascular function
(2013)
Background and Purpose Proteinase-activated receptors (PARs) and toll-like receptors (TLRs) are involved in innate immune responses. The aim of this study was to evaluate the possible cross-talk between PAR and TLR4 in ...
Assessment of Primary Colorectal Cancer Heterogeneity by Using Whole-Tumor Texture Analysis : Contrast-enhanced CT Texture as a Biomarker of 5-year Survival
(2013)
To determine if computed tomographic (CT) texture features of primary colorectal cancer are related to 5-year overall survival rate