Now showing items 11-17 of 17
The role of vehicle-nanoparticle interactions in topical drug delivery
Loading 'difficult to deliver' therapeutic agents into lipid nanoparticles (LN) is an attractive means to administer them to the skin. However, employing colloidal carriers to administer therapeutic agents from semi-solid ...
A fundamental investigation into the effects of eutectic formation on transmembrane transport
Eutectic systems enhance the permeation of therapeutic agents across biological barriers, but the mechanism by which this occurs has not previously been elucidated. Using human skin it has proven difficult to isolate the ...
A phase II study of the efficacy, tolerability and consumer acceptability of a 1% w/w terbinafine topical spray versus a currently marketed terbinafine product in the once only treatment of tinea pedis
A novel topical metered dose aerosol (MDA) spray that delivers terbinafine hydrochloride to human skin for the treatment of tinea pedis (athlete's foot) has been developed. The drug product is manufactured as a solution ...
The topical delivery of benzoyl peroxide using elegant dynamic hydrofluoroalkane foams
Formulating benzoyl peroxide (BPO) in an effective topical product is challenging due to its poor water solubility and chemical instability, but delivering BPO using elegant foams is an attractive solution to this problem. ...
Dynamic foams in topical drug delivery
Objectives: Pharmaceutical foams are not new inventions and their application in topical therapy can be traced back three decades. However, foam formulations have been gaining in popularity with over 100 patents published ...