Now showing items 11-18 of 18
Effect of abrasion induced by a rotating brush on the skin permeation of solutes with varying physicochemical properties
A transient reduction in the barrier nature of the skin can be a pre-requisite for successful (trans)dermal delivery of some drugs. The aim of this present study was to investigate and effect of a dermal abrading "rotating ...
The lost science of formulation
The current R&D outsourcing market is growing annually at ∼15%, with a predicted market of US$36 billion by 2010. However, top tier contract research organizations (CROs) are attempting to transform their profitability by ...
In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits
Biodegradable microparticles containing gentamicin were prepared using chitosan hydroglutamate (CH), hyaluronic acid (HA) and a combination Of both polymers by a solvent evaporation method. These formulations were administered ...
Protective mechanism of stabilising excipients against dehydration in the freeze-drying of proteins
To investigate the influence of type and amount of excipient on the preservation of the native structure and the biologic activity of freeze-dried lysozyme and catalase
An in vitro investigation into the effect of glycosaminoglycans on the skin partitioning and deposition of NSAIDs
Recently, Solaraze gel (Bioglan, Herts, UK) a topical hyaluronan (HA)/dictofenac formulation for the treatment of actinic keratosis has received regulatory approval in the US, Canada and Europe for the treatment of actinic ...
High performance liquid chromatography of a cyclosporin A formulation on a porous graphitic carbon column
A porous graphitic column (PGC) column was employed as a stationary phase at high temperature to effect the separation of cyclosporin A (CyA) and cyclosporin U (CyU). A robust assay for the former in liposomes was also ...
The effect of hyaluronan on the in vitro deposition of diclofenac within the skin
Hyaluronan is a glycosaminoglycan and has a protective, shock-absorbing and structure-stabilizing role in connective tissue. Recently, ii has been suggested that hyaluronan can be used as a controlled and localized delivery ...