Now showing items 11-20 of 110
Optimization of protein loaded PLGA nanoparticles manufacturing parameters following a quality-by-design approach
Development of a multivariate-based regression model for estimating the critical attributes for establishing a design-space for poly(lactic-co-glycolic acid) (PLGA) nanoparticles formulated by a double emulsion-solvent ...
Identification of excipient-protein interaction hotspots using computational approaches
Protein formulation development relies on the selection of excipients that inhibit protein-protein interactions preventing aggregation. Empirical strategies involve screening many excipient and buffer combinations using ...
Identification of new psychoactive substances using Raman spectroscopy: handheld and computational approaches.
(Research and Advances in Psychiatry, 2016-05)
At this conference, I gave a presentation on the identification of new psychoactive substances using handheld Raman spectroscopy and chemometrics.
Application of diffusion-edited and solvent suppression 1H NMR to the direct analysis of markers in valerian-hop liquid herbal products
The rising trend to consume herbal products for the treatment and/or prevention of minor ailments together with their chemical and pharmacological complexity means there is an urgent need to develop new approaches to their ...
Evidence that Diclofenac and Celecoxib are thyroid hormone receptor beta antagonists
Long term use of NSAIDs is linked to side effects such as gastric bleeding and myocardial infarction. AIMS: Use of in silico methods and pharmacology to investigate the potential for NSAIDs diclofenac, celecoxib and naproxen ...
In silico modelling of prostacyclin and other lipid mediators to nuclear receptors reveal novel thyroid hormone beta receptor antagonist properties.
Prostacyclin (PGI2) is a key mediator involved in cardiovascular homeostasis, acting predominantly on two receptor types; cell surface IP receptor and cytosolic peroxisome proliferator activated receptor (PPAR) β/δ. Having ...
Survey of knowledge of legal highs (novel psychoactive substances) amongst London pharmacists
Purpose: To determine pharmacists’ knowledge of legal highs (novel psychoactive substances; NPS). Approach: A questionnaire was handed out at 2 London pharmacist continuing education events in mid-2014. These events update ...
Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine
The interaction of quinolone and indoloquinazoline alkaloids concerning their antimycobacterial activity was studied. Methods and Results: The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) ...