Now showing items 11-20 of 55
An in vitro investigation into the effect of glycosaminoglycans on the skin partitioning and deposition of NSAIDs
Recently, Solaraze gel (Bioglan, Herts, UK) a topical hyaluronan (HA)/dictofenac formulation for the treatment of actinic keratosis has received regulatory approval in the US, Canada and Europe for the treatment of actinic ...
Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists
The preparation and biological evaluation of a series of indolopiperidine CCR2B receptor antagonists possessing a conformationally restricted C-5 linker chain in combination with a restricted piperidine ring are described. ...
Dopamine induces hyperpolarization of locust salivary gland acinar cells via D1-like receptors.
The effect of dopamine on the salivary gland acinar cells of the locust was examined using conventional intracellular recording techniques. Application of dopamine induced a reversible, dose-dependent hyperpolarization of ...
Habituating pigs for in-pen, non-invasive biophysical skin analysis
The purpose of this study was to develop a method for habituating pigs (Sus scrofa domcstica, middle white strain) to enable non-invasive, biophysical measurements of dorsal skin to be obtained on a daily basis over a ...
On-farm risk assessment of agricultural pesticides
The development of software to support planning conversion to organic agriculture
Planning is essential to the successful conversion of conventional to organic farming. Currently, advisors base planning on personal experience and expertise, historical and market data. The process can be time consuming ...
The structure of the HIV-1 Vpu ion channel: modelling and simulation studies
Vpu is an 81 amino acid auxiliary protein in HIV-1 which exhibits channel activity. We used two homo-pentameric bundles with the helical transmembrane segments derived from FTIR spectroscopy in combination with a global ...
Development of Pyrenopeziza brassicae apothecia on agar and oilseed rape debris
The development of apothecia of Pyrenopeziza brassicae (anamorph Cylindrosporium concentricum) on oilseed rape debris and compost malt agar was observed by scanning electron and light microscopy. On oilseed rape debris, ...
2,3-Butanedione monoxime increases speed of relaxation in single muscle fibres of frog
The effects of 2,3-butanedione monoxime (BDM) on intracellular Ca2+ transient and cross-bridge function were studied in frog single fibres from the anterior tibialis muscle of Rana temporaria (sarcomere length, 2.2 microm; ...
Activation of clindamycin phosphate by human skin
Aims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory ...