Now showing items 11-20 of 95
Methods for studying population structure, including sensitivity to the fungicide silthiofam, of the cereal take-all fungus, Gaeumannomyces graminis var. tritici
Field isolates (n = 144) of the wheat take-all fungus Gaeumannomyces graminis var. tritici (Ggt) were tested for sensitivity to silthiofam, a take-all-specific fungicide used as a seed treatment, and identified as A- or ...
High-pressure aerosol suspensions : A novel laser diffraction particle sizing system for hydrofluoroalkane pressurised metered dose inhalers
In this study, a novel laser diffraction particle size analysis dispersion system, capable of sizing particles in situ within suspension hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs), was developed and ...
The development of powder pocket dynamic mechanical analysis for the detection of amorphous content in salbutamol sulphate: a feasibility study
Dry powder inhalers are a commonly prescribed dosage form for the treatment of asthma. In essence they consist of an active compound in particulate form (1–5 m diameter) adhered loosely on the surface of a larger inert ...
Investigation of a reverse-phase high performance liquid chromatography (RP-HPLC) method for a weakly basic drug
Formulation development of combination drug products requires the availability of a rapid analytical method with low limits of detection, for the high-throughput analysis of the large number of samples generated. Salmeterol ...
The Broom's Barn sugar beet growth model and its adaptation to soils with varied available water content
The important environmental variables that determine sugar beet growth and yield are: temperature, radiation, rainfall, potential evapotranspiration and soil available water capacity (AWC). It is important to understand ...
Comparison of the efficacy of ramoplanin and vancomycin in both in vitro and in vivo models of clindamycin-induced Clostridium difficile infection
Treatment of Clostridium difficile infection (CDI) is limited primarily to either metronidazole or vancomycin. We compared vancomycin and a novel glycolipodepsipeptide, ramoplanin, in both hamster and in vitro gut models ...
Unilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesia
Pallidotomy paradoxically reduces the intensity of levodopa-induced dyskinesia without worsening motor symptoms. The reasons for this are not clear and no experimental study has investigated this phenomenon. The objective ...
Radioisotopes in Molecular Biology
(Wiley Blackwell, 2005-09)
H-1 NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists
The binding affinities at the human NK-1 receptor of two spirocyclic compounds were found to be similar despite being epimeric at a key stereocentre. This unexpected result prompted a thorough investigation of the solution ...