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The effect of intranasal oxytocin on the perception of affective touch and multisensory integration in anorexia nervosa : protocol for a double-blind placebo-controlled crossover study
(2019-03-15)
INTRODUCTION: Anorexia nervosa (AN) is an eating disorder characterised by restriction of energy intake, fears of gaining weight and related body image disturbances. The oxytocinergic system has been proposed as a ...
Pan-Canadian Pharmaceutical Alliance (pCPA): Timelines Analysis and Policy Implications
(2019-02-18)
This analysis follows our recent study showing that Canadian public reimbursement delays have lengthened from regulatory approval to listing decisions by public drug plans and delayed public access to innovative medicines, ...
Optimizing the bioenergy water footprint by selecting SRC willow canopy phenotypes: regional scenario simulations
(2019-02-13)
Background and Aims: Bioenergy is central for the future energy mix to mitigate climate change impacts; however, its intricate link with the water cycle calls for an evaluation of the carbon–water nexus in biomass production. ...
The effect of processing load on loss of information from short-term memory
(2019-02-07)
We report an experiment in which we varied the nature of the articulatory suppression task being performed during a filled retention interval in serial recall. During the retention interval participants performed one of ...
The Mindedness of Maternal Touch: : An Investigation of Maternal Mind-Mindedness and Mother-Infant Touch Interactions
(2019-02)
Increasing evidence shows that maternal touch may promote emotion regulation in infants, however less is known about how parental higher-order social cognition abilities are translated into tactile, affect-regulatory ...
Hyperconnectivity of the ventromedial prefrontal cortex in obsessive-compulsive disorder
(2018-11-30)
Neuroimaging research has highlighted maladaptive thalamo-cortico-striatal interactions in obsessive-compulsive disorder as well as a more general deficit in prefrontal functioning linked with compromised executive ...
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells
(2018-11-19)
Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their ...
Appraisal of patient-reported outcome measures in analogous diseases and recommendations for use in phase II and III clinical trials of pyruvate kinase deficiency
(2018-11-19)
Purpose: Pyruvate kinase deficiency (PKD) is a rare disease and understanding of its epidemiology and associated burden remains limited. With no current curative therapy, clinical manifestations can be life threatening, ...