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25C-NBOMe: preliminary data on pharmacology, psychoactive effects and toxicity of a new potent hallucinogenic drug
(2014-07-03)
Introduction. The use of novel psychoactive substances (NPSs) has rapidly increased as well as their online availability. The aim of this paper is to provide a comprehensive review of the nature and the risks associated ...
Visual performance and ocular abnormalities in deaf children and young adults : a literature review
(2014-06)
Visual defects are common in deaf individuals. Refractive error and ocular motor abnormalities are frequently reported, with hyperopia, myopia, astigmatism and anomalies of binocular vision, all showing a greater prevalence ...
Microencapsulation of a synbiotic into PLGA/alginate multiparticulate gels
(2014-05-15)
Probiotic bacteria have gained popularity as a defence against disorders of the bowel. However, the acid sensitivity of these cells results in a loss of viability during gastric passage and, consequently, a loss of efficacy. ...
Bupropion perceived as a stimulant by two patients with a previous history of cocaine misuse
(2013-12)
Background and objective. Despite animal studies having shown a generalisation of the bupropion cue to cocaine, this drug has been used in cocaine abuse with mixed results. We here aimed at describing two cases which ...
The development of a 3D immunocompetent model of human skin
(2013-09)
As the first line of defence, skin is regularly exposed to a variety of biological, physical and chemical insults. Therefore, determining the skin sensitization potential of new chemicals is of paramount importance from ...
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
(2013-07-09)
There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, ...
Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis : experience in the ERAN inception cohort
(2013-05)
Outcomes in early Rheumatoid Arthritis (RA) may be improved by rapidly establishing a stable and effective disease modifying anti-rheumatic drug (DMARD) treatment regimen. We aimed to investigate whether baseline factors ...
Assessment of Primary Colorectal Cancer Heterogeneity by Using Whole-Tumor Texture Analysis : Contrast-enhanced CT Texture as a Biomarker of 5-year Survival
(2013)
To determine if computed tomographic (CT) texture features of primary colorectal cancer are related to 5-year overall survival rate
Microvesicles and epithelial mesenchymal transition in the development of cancer
(2012-09-13)
Microvesicles released by tumour cell lines are thought to play an important role in both extracellular matrix (ECM) invasion and evasion of the immune system. We have examined the role of MVs derived from a T cell line ...
Human skeletal muscle derived microvesicles induce apoptosis in highly metastatic prostate cancer cells
(2012-09-13)
The human skeletal muscle is a highly vascularised tissue that contributes approximately 40% of the total body mass. These two factors make it a prime target for secondary cancer metastases. Surprisingly, malignant cancers ...