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Optimal tests to minimise bleeding and ischaemic complications in patients on extracorporeal membrane oxygenation
(2021-05-13)
Patients supported with extracorporeal membrane oxygenation (ECMO) experience a very high frequency of bleeding and ischaemic complications, including stroke and systemic embolism. These patients require systemic ...
Fibrinolysis in platelet thrombi
(2021-05-12)
The extent and duration of occlusive thrombus formation following an arterial atherothrombotic plaque disruption may be determined by the effectiveness of endogenous fibrinolysis. The determinants of endogenous fibrinolysis ...
Thrombotic complications in 2,928 patients with COVID-19 treated in intensive care: a systematic review
(2021-04-01)
A prothrombotic state is reported with severe COVID-19 infection, which can manifest in venous and arterial thrombotic events. Coagulopathy is reflective of more severe disease and anticoagulant thromboprophylaxis is ...
Endogenous fibrinolysis - relevance to clinical thrombosis risk assessment
(2020-12-09)
The development of an obstructive luminal thrombus is pathological and considered a failure of endogenous fibrinolysis. The consequences may be fatal, or result in lasting downstream organ damage. Therefore, assessment of ...
Angiotensin Converting Enzyme 2 may mediate disease severity in COVID-19
(2020-06-09)
Identification of vulnerability to severe coronavirus disease 2019 (COVID-19) is extremely important and might allow optimised shielding and easing of lockdown. The disease is attributed to the severe acute respiratory ...
Usefulness of the NULL-PLEASE Score to predict 1 survival in out-of hospital cardiac arrest
(2020-05-07)
Purpose: Out-of-hospital cardiac arrest (OHCA) carries a very high mortality even after successful cardiopulmonary resuscitation. Currently, information given to relatives regarding prognosis following resuscitation is ...
MINOCA presenting with STEMI- a review of incidence, aetiology, assessment and treatment
(2020-04-30)
Myocardial infarction with non-obstructive coronary artery (MINOCA) is a condition previously thought to be benign but has recently been shown to have comparable mortality to that of acute coronary syndrome with obstructive ...