Now showing items 1-7 of 7
The effects of polyvinyl alcohol on the in vitro stability and delivery of spray-dried protein particles from surfactant-free HFA 134a-based pressurised metered dose inhalers
The objective of the present study was to investigate the physical stability of spray-dried proteins within surfactant-free hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs) during prolonged storage. Two ...
The lost science of formulation
The current R&D outsourcing market is growing annually at ∼15%, with a predicted market of US$36 billion by 2010. However, top tier contract research organizations (CROs) are attempting to transform their profitability by ...
High-pressure aerosol suspensions : A novel laser diffraction particle sizing system for hydrofluoroalkane pressurised metered dose inhalers
In this study, a novel laser diffraction particle size analysis dispersion system, capable of sizing particles in situ within suspension hydrofluoroalkane (HFA) pressurised metered dose inhalers (pMDIs), was developed and ...
The development of powder pocket dynamic mechanical analysis for the detection of amorphous content in salbutamol sulphate: a feasibility study
Dry powder inhalers are a commonly prescribed dosage form for the treatment of asthma. In essence they consist of an active compound in particulate form (1–5 m diameter) adhered loosely on the surface of a larger inert ...
Hyaluronic acid : a unique topical vehicle for the localized delivery of drugs to the skin
Hyaluronic acid (HA) is a naturally occurring polyanionic, polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is present in the intercellular matrix of most vertebrate connective tissues ...
Hyaluronan: Pharmaceutical characterization and drug delivery
Hyaluronic acid ( HA), is a polyanionic polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is most frequently referred to as hyaluronan because it exists in vivo as a polyanion and not in ...