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Pharmacokinetic evaluation of intranasally administered vinyl coated lorazepam microparticles in rabbits
The intranasal (IN) administration of lorazepam is desirable in order to maximize speed of onset and minimise carry-over sedation; however, this benzodiazepine is prone to chemical hydrolysis and poor airway retention, and ...
The role of vehicle-nanoparticle interactions in topical drug delivery
Loading 'difficult to deliver' therapeutic agents into lipid nanoparticles (LN) is an attractive means to administer them to the skin. However, employing colloidal carriers to administer therapeutic agents from semi-solid ...